1215208-61-9

Basic information

• Product Name: quinolin-8-yl(3,4,5-trimethoxyphenyl)methanone
• Synonyms: quinolin-8-yl(3,4,5-trimethoxyphenyl)methanone
• CAS NO: 1215208-61-9
• Molecular Weight: 323.348
• Mol File: 1215208-61-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: quinolin-8-yl(3,4,5-trimethoxyphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: quinolin-8-yl(3,4,5-trimethoxyphenyl)methanone(1215208-61-9)
• EPA Substance Registry System: quinolin-8-yl(3,4,5-trimethoxyphenyl)methanone(1215208-61-9)

Safety Data

• Hazardous Substances Data: 1215208-61-9(Hazardous Substances Data)

Upstream product

• 86-59-9 8-carboxyquinoline 
• 40245-26-9 quinoline-8-carboxylic acid methyl ester 
• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 38707-70-9 8-formylquinoline 
• 106-49-0 p-toluidine 
• 25428-06-2 2-amino-5-methyl-acetophenone 
• 551-93-9 2-aminoacetophenone 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 

Relevant articles and documents

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

A series of aroylquinoline derivatives were synthesized and evaluated for anticancer activity. 5-Amino6-methoxy-2-aroylquinoline 15 showed more potent antiproliferative activity (IC50 values ranging from 0.2 to 0.4 nM) as compared to la (combretastatin A-4) (IC50 = 1-9-835 nM) against various human cancer cell lines and a MDR-resistant cancer cell line. Compound 15 (IC50 = 1-6 μM) exhibited more potent inhibition of tubulin polymerization than la (IC50 = 2.1 μM) and showed strong binding property to the colchicine binding site of microtubules.