1215969-79-1

Basic information

• Product Name: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
• Synonyms: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
• CAS NO: 1215969-79-1
• Molecular Weight: 204.604
• Mol File: 1215969-79-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(1215969-79-1)
• EPA Substance Registry System: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(1215969-79-1)

Safety Data

• Hazardous Substances Data: 1215969-79-1(Hazardous Substances Data)

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 1247091-38-8 C₁₉H₁₈F₂N₂O 
• 1247091-41-3 C₁₉H₁₉F₂NO₃ 
• 1247088-59-0 C₁₇H₂₁F₂NO₅ 
• 1160186-34-4 tert-butyl (3S,4R)-3-{[[2-chloro-5-(2-methoxyethyl)benzyl](cyclopropyl)amino]carbonyl}-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate 

Relevant articles and documents

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

SYNTHESIS OF 2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID

The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

NOVEL PROCESSES FOR PREPARING TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d] [1,3]- dioxol-4-yl]oxy]- 1 -ethanol.