121649-07-8

Basic information

• Product Name: (+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane
• Synonyms: (+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane
• CAS NO: 121649-07-8
• Molecular Weight: 337.314
• Mol File: 121649-07-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane(121649-07-8)
• EPA Substance Registry System: (+/-)-1-<2,5-Dimethoxy-4-(2-fluoroethyl)phenyl>-2-trifluoroacetamidopropane(121649-07-8)

Safety Data

• Hazardous Substances Data: 121649-07-8(Hazardous Substances Data)

Upstream product

• 121649-10-3 (+/-)-1-<2,5-Dimethoxy-4-(2-tosyloxyethyl)phenyl>-2-trifluoroacetamidopropane 
• 121649-06-7 (+/-)-1-<2,5-Dimethoxy-4-(2-hydroxyethyl)phenyl>-2-trifluoroacetamidopropane 
• 952016-31-8 1-[2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethyl]-2,2,5,5-tetramethyl-[1,2,5]azadisilolidine 
• 121649-03-4 1,4-Dimethoxy-2-(2-methoxy-ethyl)-5-((E)-2-nitro-propenyl)-benzene 
• 121649-02-3 2,5-Dimethoxy-4-(2-methoxy-ethyl)-benzaldehyde 
• 121649-04-5 2-[4-(2-Amino-propyl)-2,5-dimethoxy-phenyl]-ethanol 
• 16162-59-7 1,4-dimethoxy-2-(2-methoxyethyl)benzene 
• 64638-07-9 4-bromo-2,5-dimethoxyphenylisopropylamine 
• 7417-19-8 2-(2,5-dimethoxyphenyl)ethanol 

Downstream Products

• 121649-01-2 4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine 

Relevant articles and documents

High pressure nucleophilic fluoride-ion substitution reactions: Formation of fluoroalkylbenzenes

A series of 1-phenyl-2-tosyloxy- and 1-phenyl-3-tosyloxyalkanes was synthesized and then subjected to tetrabutylammonium fluoride in THF under 15 kbar (1.5 GPa), 8 kbar or 1 bar pressures. The resultant substitution and elimination reaction product distributions were analyzed. The application of pressure enhanced the progress of the fluoride-ion substitution reactions. The degree of selectivity of the one reaction over the other was found to be a function of tosylate substrate structure and the amount of pressure applied. The exclusive formation of fluoroalkanes from 1-phenyl-2-tosyloxyalkane substrates under 15 kbar pressure demonstrated the potential of the pressure method for prospective use in fluorine-18 radiolabelling applications.