1217363-55-7Relevant articles and documents
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists
Zhou, Changyou,Tang, Cheng,Chang, Eric,Ge, Min,Lin, Songnian,Cline, Eric,Tan, Carina P.,Feng, Yue,Zhou, Yun-Ping,Eiermann, George J.,Petrov, Aleksandr,Salituro, Gino,Meinke, Peter,Mosley, Ralph,Akiyama, Taro E.,Einstein, Monica,Kumar, Sanjeev,Berger, Joel,Howard, Andrew D.,Thornberry, Nancy,Mills, Sander G.,Yang, Lihu
scheme or table, p. 1298 - 1301 (2010/06/17)
Systematic structure-activity relationship (SAR) studies of a screening lead led to the discovery of a series of thiazolidinediones (TZDs) as potent GPR40 agonists. Among them, compound C demonstrated an acute mechanism-based glucose-lowering in an intraperitoneal glucose tolerance test (IPGTT) in lean mice, while no effects were observed in GPR40 knock-out mice.
