1217486-93-5

Basic information

• Product Name: 4-chloro-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-ylamine
• CAS NO: 1217486-93-5
• Molecular Weight: 321.754
• Mol File: 1217486-93-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-ylamine(1217486-93-5)
• EPA Substance Registry System: 4-chloro-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-ylamine(1217486-93-5)

Safety Data

• Hazardous Substances Data: 1217486-93-5(Hazardous Substances Data)

Upstream product

• 1357476-67-5 4-bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine 
• 1357476-66-4 2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4(1H)-one 
• 1357476-64-2 2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4H-pyran-4-one 
• 1163707-53-6 3,3,3-trifluoro-2,2-dimethylpropanoyl chloride 
• 889940-13-0 3,3,3-trifluoro-2,2-dimethylpropanoic acid 

Relevant articles and documents

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Phosphatidylinositol-3-kinase α (PI3Kα) is a therapeutic target of high interest in anticancer drug research. On the basis of a binding model rationalizing the high selectivity and potency of a particular series of 2-aminothiazole compounds in inhibiting PI3Kα, a medicinal chemistry program has led to the discovery of the clinical candidate NVP-BYL719.