121822-56-8

Basic information

• Product Name: 27-hydroxyoctacosanoic acid
• Synonyms: 27-hydroxyoctacosanoic acid
• CAS NO: 121822-56-8
• Molecular Formula: C28H56 O3
• Molecular Weight: 0
• Mol File: 121822-56-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 558.7°Cat760mmHg
• Flash Point: 305.7°C
• Appearance: /
• Density: 0.912g/cm³
• Vapor Pressure: 8.28E-15mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 27-hydroxyoctacosanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 27-hydroxyoctacosanoic acid(121822-56-8)
• EPA Substance Registry System: 27-hydroxyoctacosanoic acid(121822-56-8)

Safety Data

• Hazardous Substances Data: 121822-56-8(Hazardous Substances Data)

Usage

General Description

27-hydroxyoctacosanoic acid is a long-chain fatty acid derived from the omega-3 polyunsaturated fatty acid called docosahexaenoic acid (DHA). It is a biologically active compound that has been found to be present in the brain and nervous system, as well as in certain tissues and organs. 27-hydroxyoctacosanoic acid has been shown to have anti-inflammatory and neuroprotective properties, making it potentially beneficial for conditions such as Alzheimer's disease, multiple sclerosis, and other neurodegenerative disorders. It is also being studied for its potential role in the regulation of lipid metabolism and energy balance, and may have implications for the treatment of metabolic disorders such as obesity and diabetes. Overall, 27-hydroxyoctacosanoic acid is a compound with diverse potential therapeutic uses and is an area of ongoing research and interest in the scientific community.

InChI:InChI=1/C28H56O3/c1-27(29)25-23-21-19-17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18-20-22-24-26-28(30)31/h27,29H,2-26H2,1H3,(H,30,31)

Relevant articles and documents

Structure of the unusual Sinorhizobium fredii HH103 lipopolysaccharide and its role in symbiosis

Rhizobia are soil bacteria that form important symbiotic associations with legumes, and rhizobial surface polysaccharides, such as K-antigen polysaccharide (KPS) and lipopolysaccharide (LPS), might be important for symbiosis. Previously, we obtained a mutant of Sinorhizobium fredii HH103, rkpA, that does not produce KPS, a homopolysaccharide of a pseudaminic acid derivative, but whose LPS electrophoretic profile was indistinguishable from that of the WT strain. We also previously demonstrated that the HH103 rkpLMNOPQ operon is responsible for 5-acetamido-3,5,7,9-tetradeoxy-7-(3-hydroxybutyramido)-L-glyc-ero-L-manno-nonulosonic acid [Pse5NAc7(3OHBu)] production and is involved in HH103 KPS and LPS biosynthesis and that an HH103 rkpM mutant cannot produce KPS and displays an altered LPS structure. Here, we analyzed the LPS structure of HH103 rkpA, focusing on the carbohydrate portion, and found that it contains a highly heterogeneous lipid A and a peculiar core oligosaccharide composed of an unusually high number of hexuronic acids containing b-configured Pse5NAc7(3OHBu). This pseudaminic acid derivative, in its a-configuration, was the only structural component of the S. fredii HH103 KPS and, to the best of our knowledge, has never been reported from any other rhizobial LPS. We also show that Pse5NAc7(3OHBu) is the complete or partial epitope for a mAb, NB6-228.22, that can recognize the HH103 LPS, but not those of most of the S. fredii strains tested here. We also show that the LPS from HH103 rkpM is identical to that of HH103 rkpA but devoid of any Pse5NAc7(3OHBu) residues. Notably, this rkpM mutant was severely impaired in symbiosis with its host, Macroptilium atropurpureum.