121885-10-7

Basic information

• Product Name: N-T-BUTYL PYRAZINE CARBOXAMIDE
• Synonyms: N-T-BUTYL PYRAZINE CARBOXAMIDE;N-(tert-butyl)pyrazine-2-carboxamide
• CAS NO: 121885-10-7
• Molecular Formula: C9H13N3O
• Molecular Weight: 179.22
• Product Categories: Pyrazines
• Mol File: 121885-10-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 361.268 °C at 760 mmHg
• Flash Point: 172.289 °C
• Appearance: /
• Density: 1.081 g/cm³
• PKA: 13.61±0.46(Predicted)
• CAS DataBase Reference: N-T-BUTYL PYRAZINE CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-T-BUTYL PYRAZINE CARBOXAMIDE(121885-10-7)
• EPA Substance Registry System: N-T-BUTYL PYRAZINE CARBOXAMIDE(121885-10-7)

Safety Data

• Hazardous Substances Data: 121885-10-7(Hazardous Substances Data)

Usage

General Description

N-T-butyl pyrazine carboxamide, also known as ethyl 2-(5-tert-butyl-1,3-dimethyl-1H-pyrazol-3-yl)acetate, is a chemical compound that is commonly used as a flavoring agent in the food and beverage industry. It is a colorless to pale yellow liquid with a characteristic odor, and it is known for its nutty, roasted, and chocolate-like aroma. N-T-butyl pyrazine carboxamide is often added to products such as coffee, chocolate, and savory snacks to enhance their flavor profile. The compound is considered safe for consumption in small quantities and is approved for use as a food additive by regulatory agencies.

Upstream product

• 19847-10-0 pyrazinoyl chloride 
• 75-64-9 tert-butylamine 
• 201230-82-2 carbon monoxide 
• 32111-21-0 2-iodopyrazine 
• 19847-12-2 2-pyrazine carbonitrile 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 98-97-5 2-pyrazylcarboxylic acid 
• 306990-94-3 (1H-benzo[d][1,2,3]triazol-1-yl)(pyrazin-2-yl)methanone 

Downstream Products

• 166941-47-5 2(S)-(tert-butylcarboxamido)piperazine 
• 166740-50-7 (S)-4-[(2S,4R)-4-Benzyl-5-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-5-oxo-pentyl]-3-tert-butylcarbamoyl-piperazine-1-carboxylic acid tert-butyl ester 
• 150378-17-9 indinavir 
• 150323-38-9 [14C]-N-Dealkyl Indinavir 
• 158380-45-1 (S)-3-tert-Butylcarbamoyl-4-(R)-1-oxiranylmethyl-piperazine-1-carboxylic acid tert-butyl ester 
• 150323-35-6 t-butyl (S)-3-(tert-butylcarbamoyl)-piperazine-1-carboxylate 
• 143769-17-9 3-phenylhydroxymethyl-2-N-t-butylpyrazinamide 

Relevant articles and documents

Homogeneous catalytic aminocarbonylation of nitrogen-containing iodo-heteroaromatics. Synthesis of N-substituted nicotinamide related compounds

Various primary and secondary amines, including amino acid methyl esters, were used as nucleophiles in palladium-catalysed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine. N-Substituted nicotinamides and 3-pyridyl-glyoxylamides (2-oxo-carboxamide type derivatives) of potential biological importance can be obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The latter examples can be obtained in synthetically acceptable yields by using elevated carbon monoxide pressure. On the contrary, N-alkyl/aryl-carboxamides were obtained exclusively in the whole pressure range by using 2-iodopyridine and iodopyrazine.

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.

Process for preparing N-tert-butyl-2-pyrazinecarboxamide and N-tert-butyl-2-piperazinecarboxamide

A process for preparing a N-tert-butyl-2-pyrazinecarboxamide having the formula (2): STR1 which comprises reacting a cyanopyrazine having the formula (1): STR2 with tert-butyl alcohol in the presence of sulfuric acid and a process for preparing a N-tert-butyl-2-piperazine-carboxamide having the formula (3): STR3 which comprises hydrogenating of said N-tert-butyl-2-pyrazinecarboxamide having the formula (2) in the presence of Raney nickel or Raney cobalt.