1219035-08-1

Basic information

• Product Name: 4-[3,5-bis(trifluoromethyl)phenyl]-1,3,5-trimethylpyrazole
• Synonyms: 4-[3,5-bis(trifluoromethyl)phenyl]-1,3,5-trimethylpyrazole
• CAS NO: 1219035-08-1
• Molecular Weight: 322.253
• Mol File: 1219035-08-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[3,5-bis(trifluoromethyl)phenyl]-1,3,5-trimethylpyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3,5-bis(trifluoromethyl)phenyl]-1,3,5-trimethylpyrazole(1219035-08-1)
• EPA Substance Registry System: 4-[3,5-bis(trifluoromethyl)phenyl]-1,3,5-trimethylpyrazole(1219035-08-1)

Safety Data

• Hazardous Substances Data: 1219035-08-1(Hazardous Substances Data)

Upstream product

• 1072-91-9 1,3,5-trimethyl-1H-pyrazole 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 

Relevant articles and documents

Palladium-catalyzed direct arylation of pyrazole derivatives: A green access to 4-arylpyrazoles

1,3,5-Trisubstituted pyrazoles were found to be suitable partners for palladium-catalyzed direct arylation via C-H activation/functionalization using aryl bromides. The reaction conditions and the catalyst have a determining influence on the yields. The system using palladium(II) acetate as the catalyst, potassium acetate as the base, and N,N-dimethylacetamide as the solvent promotes selective 4-arylations in moderate to high yields. Several aryl and heteroaryl bromide derivatives have been employed successfully; their electronic properties have a decisive influence on the yields of coupling products. Electron-poor aryl bromides gave satisfactory results, whereas the electron-rich ones gave lower yields. Georg Thieme Verlag Stuttgart - New York.