121925-53-9

Basic information

• Product Name: 4-ethoxy-4-oxo-2-phenylbutanoic acid
• Synonyms: 4-ethoxy-4-oxo-2-phenylbutanoic acid
• CAS NO: 121925-53-9
• Molecular Weight: 222.241
• Mol File: 121925-53-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-ethoxy-4-oxo-2-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethoxy-4-oxo-2-phenylbutanoic acid(121925-53-9)
• EPA Substance Registry System: 4-ethoxy-4-oxo-2-phenylbutanoic acid(121925-53-9)

Safety Data

• Hazardous Substances Data: 121925-53-9(Hazardous Substances Data)

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 124-38-9 carbon dioxide 
• 103-82-2 phenylacetic acid 
• 105-36-2 ethyl bromoacetate 
• 4192-77-2 ethyl cinnamate 
• 64-17-5 ethanol 
• 1131-15-3 2-phenylsuccinic anhydride 

Downstream Products

• 18734-79-7 (SR,RS)-2-methyl-3-phenylsuccinic acid 
• 18734-79-7 (SR,SR)-2-methyl-3-phenylsuccinic acid 
• 132545-36-9 1-Methyl-4-ethyl 2-phenylsuccinate 
• 112607-26-8 (S)-α-Phenyl-γ-butyrolactone 
• 112607-27-9 (R)-α-Phenyl-γ-butyrolactone 
• 1008-73-7 (R)-4-phenyl-4,5-dihydrofuran-2(3H)-one 
• 68844-05-3 4-phenyldihydrofuran-2-one 
• 167834-23-3 ethyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoate 
• 5653-90-7 2-benzyl-3-phenyl-succinic acid 
• 32980-51-1 2-n-Butyl-3-phenylbernsteinsaeure 
• 32980-44-2 2-Phenyl-3-benzylbernsteinsaeure-4-ethylester 
• 32980-50-0 2-Benzhydryliden-3-phenylbernsteinsaeure 
• 32980-46-4 2-Phenyl-3-n-butylbernsteinsaeure-4-ethylester 

Relevant articles and documents

Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes

We describe a photoinduced copper-catalyzed asymmetric radical decarboxylative alkynylation of bench-stable N-hydroxyphthalimide(NHP)-type esters of racemic alkyl carboxylic acids with terminal alkynes, which provides a flexible platform for the construction of chiral C(sp3)?C(sp) bonds. Critical to the success of this process are not only the use of the copper catalyst as a dual photo- and cross-coupling catalyst but also tuning of the NHP-type esters to inhibit the facile homodimerization of the alkyl radical and terminal alkyne, respectively. Owing to the use of stable and easily available NHP-type esters, the reaction features a broader substrate scope compared with reactions using the alkyl halide counterparts, covering (hetero)benzyl-, allyl-, and aminocarbonyl-substituted carboxylic acid derivatives, and (hetero)aryl and alkyl as well as silyl alkynes, thus providing a vital complementary approach to the previously reported method.

Practical synthesis of diethyl phenylsuccinate by Mg-promoted carboxylation of ethyl cinnamate

Mg-promoted reduction of ethyl cinnamate (1a) in the presence of carbon dioxide gave a mixture of β-carboxylated compound 2a and α,β-dicarboxylated compound 3a. Similar reductive carboxylation of 1a followed by acidic decarboxylation of one of the two geminal carboxyl groups of the generated 3a and esterification afforded selective formation of diethyl phenylsuccinate (2a) in good yield.

HIGHLY REGIOSELECTIVE RING-OPENING OF α-SUBSTITUTED CYCLIC ACID ANHYDRIDES CATALYZED BY LIPASE

Lipase Amano P irreversibly catalyzed a ring-opening of α-substituted cyclic acid anhydrides 1 preferentially at the less hindered carbonyl group to give monoesters with high regioselectivity.