121985-99-7

Basic information

• Product Name: (R)-2-METHOXYMANDELONITRILE
• Synonyms: (R)-2-METHOXYMANDELONITRILE
• CAS NO: 121985-99-7
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 0
• Mol File: 121985-99-7.mol
• Article Data: 45

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-2-METHOXYMANDELONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-METHOXYMANDELONITRILE(121985-99-7)
• EPA Substance Registry System: (R)-2-METHOXYMANDELONITRILE(121985-99-7)

Safety Data

• Hazardous Substances Data: 121985-99-7(Hazardous Substances Data)

Usage

General Description

"(R)-2-Methoxymandelonitrile" is a chemical compound with the molecular formula C9H9NO2. It is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R)- designation indicates the stereochemistry of this particular molecule. (R)-2-METHOXYMANDELONITRILE is commonly used as an intermediate in the synthesis of various pharmaceuticals and fine chemicals. It is also known for its almond-like odor and is often used in the fragrance industry as a component in perfumes and cosmetics. Additionally, (R)-2-Methoxymandelonitrile has been studied for its potential anti-cancer properties and is being researched for its use in cancer treatment.

Upstream product

• 82128-71-0 2-(2-methyloxyphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 135-02-4 ortho-anisaldehyde 
• 4746-48-9 2-hydroxy-2,2-diphenylacetonitrile 
• 74-90-8 hydrogen cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 
• 90-02-8 salicylaldehyde 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 143-33-9 sodium cyanide 
• 613-90-1 benzoyl cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 123311-39-7 Carbonic acid (R)-cyano-(2-methoxy-phenyl)-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 123311-54-6 Carbonic acid (S)-cyano-(2-methoxy-phenyl)-methyl ester (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 135-02-4 ortho-anisaldehyde 
• 89709-23-9 (R)-2-methoxymandelic acid 
• 96929-45-2 α-amino-2-methoxybenzeneacetonitrile 
• 1434652-66-0 (R)-2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethan-1-ol 
• 1630859-22-1 2-(tert-butyldiphenylsilyloxy)-2-(2-methoxyphenyl)acetonitrile 
• 1476803-99-2 C₂₃H₂₀N₂O₄ 
• 26767-06-6 2-(2-methoxyphenyl)-2-oxoacetic acid 
• 1476804-82-6 C₂₃H₁₈N₂O₃ 
• 41873-63-6 (2-Carboxymethoxy-phenyl)-essigsaeure 
• 553-86-6 benzofuran-2(3H)-one 

Relevant articles and documents

Enzyme Optimization and Process Development for a Scalable Synthesis of (R)-2-Methoxymandelic Acid

The rational protein engineering of wild type BCJ2315 nitrilase and its use in the development of a one-pot, enantioselective, dynamic kinetic resolution for (R)-2-methoxymandelic acid is reported. Through a combination of molecular docking and B-factor a

CO2-Enabled Cyanohydrin Synthesis and Facile Iterative Homologation Reactions**

Thermodynamic and kinetic control of a chemical process is the key to access desired products and states. Changes are made when a desired product is not accessible; one may manipulate the reaction with additional reagents, catalysts and/or protecting groups. Here we report the use of carbon dioxide to accelerate cyanohydrin synthesis under neutral conditions with an insoluble cyanide source (KCN) without generating toxic HCN. Under inert atmosphere, the reaction is essentially not operative due to the unfavored equilibrium. The utility of CO2-mediated selective cyanohydrin synthesis was further showcased by broadening Kiliani–Fischer synthesis under neutral conditions. This protocol offers an easy access to a variety of polyols, cyanohydrins, linear alkylnitriles, by simply starting from alkyl- and arylaldehydes, KCN and an atmospheric pressure of CO2.

Preparation method of alpha-hydroxypyridine by acetone cyanohydrin

The invention relates to a preparation method of alpha-hydroxypyridine by acetone cyanohydrin, and relates to a preparation method of alpha-hydroxypyridine. The method solves the problems that the existing preparation method of the alpha-hydroxypyridine is low in yield, big in catalyst toxicity, high in price, complex in preparation method, and long in reaction time. The method includes steps of firstly, immersing cation exchange resin in 20% by weight of organic amine methanol solution; filtering, washing and drying the solution to obtain catalyst; secondly, dissolving acetone cyanohydrin and aromatic aldehyde in the methanol, and adding catalyst to react and obtain the alpha-hydroxypyridine; filtering the catalyst, depressurizing and evaporating methanol and acetone; extracting and separating the methanol and acetone; after drying, rotationally evaporating and removing ethyl acetate to obtain the alpha-hydroxypyridine. The method applies the simple and easily-prepared catalyst, and the reaction can be completed under room temperature condition; the reaction yield is up to over 95%. The operation method is simple and easy to practice, and the catalyst can be repeatedly used and is more applicable to the industrial production. The preparation method is applied to prepare alpha-hydroxypyridine.