1220015-97-3

Basic information

• Product Name: N,N-dimethyl-7-(4-tolyl)indoline-1-carboxamide
• Synonyms: N,N-dimethyl-7-(4-tolyl)indoline-1-carboxamide
• CAS NO: 1220015-97-3
• Molecular Weight: 280.37
• Mol File: 1220015-97-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N,N-dimethyl-7-(4-tolyl)indoline-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-7-(4-tolyl)indoline-1-carboxamide(1220015-97-3)
• EPA Substance Registry System: N,N-dimethyl-7-(4-tolyl)indoline-1-carboxamide(1220015-97-3)

Safety Data

• Hazardous Substances Data: 1220015-97-3(Hazardous Substances Data)

Upstream product

• 61589-18-2 N,N-dimethylindoline-1-carboxamide 
• 5720-05-8 4-methylphenylboronic acid 
• 108-88-3 toluene 
• 624-31-7 4-tolyl iodide 

Relevant articles and documents

Exceptionally mild palladium(II)-catalyzed dehydrogenative C-H/C-H arylation of indolines at the C-7 position under air

An improved method for the dehydrogenative C-H/C-H cross-coupling at the C-7 position of indolines containing a urea as a directing group is reported. The new protocol is a rare example of an aerobic palladium(II)-catalyzed cross dehydrogenative coupling (CDC) reaction that proceeds at low temperature. The use of either Cu(OAc)2 in an open flask or dioxygen (balloon) at 50 °C tolerates indolines not substituted at C-2 and C-3, thereby extending the scope of the previous method that suffers from indoline-to-indole oxidation.

Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of aryl ureas in water

An efficient protocol for the direct synthesis of 8-arylated tetrahydroquinolines via Pd-catalyzed ortho-arylation of aryl ureas with aryl iodides was developed. The reaction proceeded smoothly in water under ligand-free and surfactant-free conditions, pr