122024-75-3

Basic information

• Product Name: 3-BENZYLOXYCINNAMIC ACID
• Synonyms: 3-(Benzyloxy)cinnamicacid; m-Benzyloxycinnamic acid
• CAS NO: 122024-75-3
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.29
• Product Categories: Aromatic Cinnamic Acids, Esters and Derivatives
• Mol File: 122024-75-3.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BENZYLOXYCINNAMIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZYLOXYCINNAMIC ACID(122024-75-3)
• EPA Substance Registry System: 3-BENZYLOXYCINNAMIC ACID(122024-75-3)

Safety Data

• Hazardous Substances Data: 122024-75-3(Hazardous Substances Data)

Usage

General Description

3-BENZYLOXYCINNAMIC ACID, also known as 4-(3-phenylpropoxy)benzoic acid, is a chemical compound with a molecular formula of C16H14O3. It is a derivative of cinnamic acid and is commonly used in organic synthesis. 3-BENZYLOXYCINNAMIC ACID has a benzyl group attached to the oxygen atom of the cinnamic acid, which imparts certain physical and chemical properties to the molecule. It is commonly used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. 3-BENZYLOXYCINNAMIC ACID has potential applications in drug design, as well as in the development of new materials and chemical processes. It is important from a research standpoint, as it can serve as a building block for the creation of more complex organic molecules.

Upstream product

• 14755-02-3 3-hydroxy-trans-cinnamic acid 
• 100-39-0 benzyl bromide 
• 141-82-2 malonic acid 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 14755-02-3 3-hydroxycinnamic acid 
• 3943-95-1 m-coumaric acid methyl ester 
• 495399-41-2 methyl 3-(3-benzyloxyphenyl)propenoate 
• 1026884-98-9 benzyl (E)-3'-benzyloxycinnamate 
• 208836-69-5 3-(3'-benzyloxyphenyl)-(E)-propenoic acid ethyl ester 

Downstream Products

• 1259977-93-9 methyl 5-(benzyloxy)-3-chlorobenzo[b]thiophene-2-carboxylate 
• 1259977-97-3 kb-NB₁₂₃-66 
• 1259978-05-6 Kb-NB₁₆₅-89 
• 1233533-04-4 kb-NB142-70 
• 122024-71-9 3-Chloro-5-(phenylmethoxy)-benzo[b]thiophene-2-carbonyl chloride 
• 172832-10-9 3,4-dihydro-9-methoxy[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one 
• 1418183-67-1 (R)-2-ethylhexyl (E)-3-[3-(benzyloxy)phenyl]acrylate 
• 1418183-68-2 C₁₇H₂₆O₃ 
• 155697-42-0 (E)-3-(3-(benzyloxy)phenyl)prop-2-en-1-ol 
• 175591-23-8 tapentadol 
• 1443156-34-0 (2R,3R)-3-(3-(benzyloxy)phenyl)-2-methylpent-4-enal 
• 1367878-83-8 (2R,3R)-3-(3-(benzyloxy)phenyl)-N,N,2-trimethylpent-4-en-1-amine 
• 1443156-35-1 (2R,3R)-3-(3-(benzyloxy)phenyl)-N,N,2-trimethylpent-4-en-1-amine hydrochloride 

Relevant articles and documents

Synthesis of novel 1-phenyl-benzopyrrolizidin-3-one derivatives and evaluation of their cytoneuroprotective effects against NMDA-induced injury in PC12 cells

A range of novel 1-phenyl-benzopyrrolizidin-3-one derivatives were synthesized and evaluated for neuroprotective effects against N-methyl-?-aspartate (NMDA)-induced injury in PC12 cells. Interestingly, derivatives that 1-phenyl moiety bearing electron-donating group, especially benzyloxy, and the trans-forms exhibited better protective activity against NMDA-induced neurotoxicity. Compound 11 m demonstrated the best neuroprotective potency and shown a dose-dependent prevention. The increased intracellular calcium (Ca2+) influx caused by NMDA in PC12 cells was reversed in the case of compound 11 m pretreatment at 15 μM. These results suggested that the synthesized 1-phenyl-benzopyrrolizidin-3-one derivatives exerted neuroprotective effect on NMDA-induced excitotoxicity in PC12 cells associated with inhibition of Ca2+ overload and can be further optimized for the development of neuroprotective agents.

Structural isomers of cinnamic hydroxamic acids block HCV replication via different mechanisms

A set of ortho-, meta- and para-substituted cinnamic hydroxamic acids (CHAs) was synthesized. In each series of structural isomers, a phenyl substituent was linked to an aromatic ring of the parent cinnamic acid via a linker of one to four atoms in length

Compositions for the prevention or treatment of neurodegenerative disease containing alkoxyphenylpropenone derivatives or pharmaceutically acceptable salts thereof as an active ingredient

PURPOSE: An alkoxyphenylpropenone derivative is provided to efficiently use as a pharmaceutical composition for preventing or treating a degenerative brain disease; or pharmaceutical composition for protecting a brain cell by having an excellent protecting effect of the brain cell. CONSTITUTION: An alkoxyphenylpropenone derivative or a pharmaceutically acceptable salt thereof is indicated as below chemical formula 1; and R^1 is hydrogen or O-R^4; R^2 is hydrogen or O-R^5; R^3 is hydroxy, O-R^6 or -NR^7R^8; R^4, R^5 and R^6 are C_1-C_12 straight chain or a side chain alkyl, C_2-C_12 straight chain or a side chain alkenyl, and unsubstituted or C_5-C_6 aryl which is substituted as C_1-C_4 straight chain, or a side chain alkoxy, C_5-C_6 aryl C_1-C_4 alkyl; R^7 is hydrogen, C_1-C_4 straight chain, or a side chain alkyl; R^8 is hydrogen, the C_1-C_4 straight chain or the side chain alkyl, and the C5-C6 aryl which is unsubstituted or hydroxy-substituted, the C1-C4 alkyl or the C5-C6.