1220531-61-2

Basic information

• Product Name: (R)-3-(3,5-dimethyl-phenyl)cyclohexanone
• Synonyms: (R)-3-(3,5-dimethyl-phenyl)cyclohexanone
• CAS NO: 1220531-61-2
• Molecular Weight: 202.296
• Mol File: 1220531-61-2.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (R)-3-(3,5-dimethyl-phenyl)cyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(3,5-dimethyl-phenyl)cyclohexanone(1220531-61-2)
• EPA Substance Registry System: (R)-3-(3,5-dimethyl-phenyl)cyclohexanone(1220531-61-2)

Safety Data

• Hazardous Substances Data: 1220531-61-2(Hazardous Substances Data)

Upstream product

• 930-68-7 cyclohexenone 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 556-96-7 5-bromo-1,3-xylene 

Relevant articles and documents

Organic Solvent-free Asymmetric 1,4-Addition in Liquid- or Solid-State using Conventional Stirring Catalyzed by a Chiral Rhodium Complex Developed as a Homogeneous Catalyst

Organic solvent-free asymmetric 1,4-addition of arylboronic acids to enone substrates was performed by using a chiral rhodium complex catalyst developed as a homogeneous catalyst. Reactions catalyzed by [RhOH(cod)]2 with chiral diphosphine ligands in liquid- or solid-state proceeded to give chiral 1,4-adducts in high yield with enantioselectivities up to ca. 100 % ee by conventional stirring without mechanochemistry such as ball milling. The solid-state reactions under a static condition also proceeded, but with a slight decrease in enantioselectivity of the 1,4-adduct. SEM observations of the solid-state reactions indicated that no nanoparticles catalyst was generated. The organic solvent-free reaction could be applied to gram-scale synthesis by performing a greener purification using a minimum necessary organic solvent.

Chiral Phosphorus-Olefin Ligands for the RhI-Catalyzed Asymmetric Addition of Aryl Boronic Acids to Electron-Deficient Olefins

New chiral phosphorus-olefin hybrid ligands derived from the rigid "privileged" l-proline have been conveniently prepared and applied in the rhodium-catalyzed asymmetric arylation of electron-deficient olefins with arylboronic acids at room temperature; t

Polymer-incarcerated chiral Rh/Ag nanoparticles for asymmetric 1,4-addition reactions of arylboronic acids to enones: Remarkable effects of bimetallic structure on activity and metal leaching

Robust and highly active bimetallic Rh nanoparticle (NP) catalysts, PI/CB Rh/Ag, have been developed and applied to the asymmetric 1,4-addition of arylboronic acids to enones without leaching of the metals. We found that the structures of the bimetallic Rh/Ag catalysts and chiral ligands strongly affect their catalytic activity and the amount of metal leaching. PI/CB Rh/Ag could be recycled several times by simple operations while keeping high yields and excellent enantioselectivities. To show the versatility of the PI/CB Rh/Ag catalyst, a one-pot, oxidation-asymmetric 1,4-addition reaction of an allyl alcohol and an arylboronic acid was demonstrated by combining the PI/CB Rh/Ag catalyst with PI/CB Au as an aerobic oxidation catalyst.