1220627-08-6Relevant articles and documents
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
Onions, Stuart T.,Ito, Kazuhiro,Charron, Catherine E.,Brown, Richard J.,Colucci, Marie,Frickel, Fritz,Hardy, George,Joly, Kevin,King-Underwood, John,Kizawa, Yasuo,Knowles, Ian,Murray, P. John,Novak, Andrew,Rani, Anjna,Rapeport, Garth,Smith, Alun,Strong, Peter,Taddei, David M.,Williams, Jonathan G.
, p. 1727 - 1746 (2016/03/25)
The discovery of a novel series of therapeutic agents that has been designed and optimized for treating chronic obstructive pulmonary disease is reported. The pharmacological strategy was based on the identification of compounds that inhibit a defined subset of kinase enzymes modulating inflammatory processes that would be effective against steroid refractory disease and exhibit a sustained duration of action after inhaled delivery.
NOVEL COMPOUNDS
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, (2011/10/31)
There is provided inter alia a compound of formula (I) wherein R1, J, Ar, L, X, R3 and R4 are as defined in the specification, for use in the treatment of inflammatory disorders.