1220703-07-0

Basic information

• Product Name: (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol
• Synonyms: (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol
• CAS NO: 1220703-07-0
• Molecular Weight: 611.523
• Mol File: 1220703-07-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol(1220703-07-0)
• EPA Substance Registry System: (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol(1220703-07-0)

Safety Data

• Hazardous Substances Data: 1220703-07-0(Hazardous Substances Data)

Upstream product

• 875446-37-0 anacetrapib 
• 1383814-88-7 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanamine 
• 1383676-71-8 4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-carbonitrile 
• 877384-16-2 benzyl (1S,2R)-2-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxy-1-methylethylcarbamate 
• 1152029-16-7 (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol 
• 871917-79-2 benzyl {(1S)-2-[3,5-bis(trifluoromethyl)phenyl]-1-methyl-2-oxoethyl}carbamate 
• 1620289-77-1 (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[(E)-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methylidene)amino]propan-1-ol 
• 875551-32-9 4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde 
• 875548-97-3 (4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol 
• 875446-29-0 [4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid 
• 702641-05-2 [2-iodo-5-(trifluoromethyl)phenyl]methanol 

Downstream Products

• 1220703-22-9 tert-butyl {(1S,2R)-2-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-1-methylethyl}{[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}carbamate 
• 875446-37-0 anacetrapib 

Relevant articles and documents

Preparation method of Anacetrapib

The invention provides a preparation method of Anacetrapib. The method includes: firstly subjecting a compound 1 to ylide reaction to obtain olefin, and then carrying out epoxidation to obtain a compound 2; then, reacting the compound 2 with a compound 3 in a solvent to prepare a compound 4, finally subjecting the compound 4 to condensation reaction to obtain a compound 5, and conducting deprotection cyclization on the compound 5 so as to obtain a compound 6 Anacetrapib. The operation method provided by the invention is simple, has low requirement for water in the reaction system, is low in process cost, and is suitable for industrial application.

PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS

The compounds of Formula I are prodrugs of CETP inhibitors having a central oxazolidinone ring. The compounds cyclize by the elimination of HX to form an oxazolidinone ring after administration to a patient.