1220831-49-1

Basic information

• Product Name: 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione
• Synonyms: 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione
• CAS NO: 1220831-49-1
• Molecular Weight: 377.486
• Mol File: 1220831-49-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione(1220831-49-1)
• EPA Substance Registry System: 2-{3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl}isoindole-1,3-dione(1220831-49-1)

Safety Data

• Hazardous Substances Data: 1220831-49-1(Hazardous Substances Data)

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 1013-22-5 1-(2,3-dimethylphenyl)piperazine 
• 80836-96-0 1-(2,3-dimethylphenyl)piperazine hydrochloride 

Downstream Products

• 1292802-53-9 C₂₈H₃₃FN₆O 
• 1292802-40-4 C₂₈H₃₄N₆O 
• 938307-34-7 3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propylamine 

Relevant articles and documents

Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors

Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant anti-proliferative activities against DU-145, HT-29, HCT-116, A375P and MCF-7 cancer cell lines. The selected compounds were tested against Her2, a client protein of Hsp90, and showed significant reduction in Her2 protein expression. Compound 6b was found the most potent, reduced Her2 protein expression levels and induced Hsp70 protein expression levels significantly.

Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

In the continuing search for novel compounds targeting serotonin 5-HT 2A, 5-HT2C, and serotonin transporter, new arylpiperazine-containing pyrrole 3-carboxamide derivatives were synthesized and evaluated. Based on the lead reported previously, structural modifications regarding N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-1,2-dimethyl-5- phenyl-1H-pyrrole-3-carboxamide 5, were accomplished for improvements in not only binding affinity against serotonin receptors and transporter, but also in hERG channel inhibition. Along the line, both the forced swimming tests and spontaneous locomotor activity tests were performed to distinguish between antidepressant activity and false positive results. As potential antidepressant agents, both 2,4-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide and 5-tert-butyl-2-methyl-1H-pyrrole-3-carboxamide derivatives exhibited favorable in vitro and in vivo activities, warranting further investigation around these scaffolds.

Arylpiperazine-containing pyrimidine 4-carboxamide derivatives targeting serotonin 5-HT2A, 5-HT2C, and the serotonin transporter as a potential antidepressant

Pyrimidine usually has good pharmacokinetic properties as a drug substance and considerable efforts have been devoted to develop pyrimidine derivatives into drug candidates. Arylpiperazine-containing pyrimidine 4-carboxamide derivatives were synthesized and evaluated for binding to serotonin receptors and transporter. Pyrimidine derivatives showed good antidepressant activity in FST (forced swimming test) animal model and also displayed no appreciable inhibitory activity against hERG channel blocking assay. Herein SAR studies of pyrimidine derivatives targeting serotonin receptors and transporter will be disclosed.