1221003-78-6

Basic information

• Product Name: (2E)-N-{[2-benzylidenehydrazino](imino)methyl}-3-phenylacrylamide
• Synonyms: (2E)-N-{[2-benzylidenehydrazino](imino)methyl}-3-phenylacrylamide
• CAS NO: 1221003-78-6
• Molecular Weight: 292.34
• Mol File: 1221003-78-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E)-N-{[2-benzylidenehydrazino](imino)methyl}-3-phenylacrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-{[2-benzylidenehydrazino](imino)methyl}-3-phenylacrylamide(1221003-78-6)
• EPA Substance Registry System: (2E)-N-{[2-benzylidenehydrazino](imino)methyl}-3-phenylacrylamide(1221003-78-6)

Safety Data

• Hazardous Substances Data: 1221003-78-6(Hazardous Substances Data)

Upstream product

• 2757-04-2 phenyl cinnamate 
• 3357-37-7 2-benzylidenehydrazinecarboximidamide 

Relevant articles and documents

Novel molecular hybrids of cinnamic acids and guanylhydrazones as potential antitubercular agents

In an attempt to identify potential new agents active against tuberculosis, 20 novel phenylacrylamide derivatives incorporating cinnamic acids and guanylhydrazones were synthesized using microwave assisted synthesis. Activity of the synthesized compounds was evaluated using resazurin microtitre plate assay (REMA) against Mycobacterium tuberculosis H37Rv. Based on empirical structure-activity relationship data it was observed that both steric and electronic parameters play major role in the activity of this series of compounds. Compound 7s (2E)-N-((-2-(3,4-dimethoxybenzylidene) hydrazinyl) (imino) methyl)-3-(4-methoxyphenyl) acrylamide showed MIC of 6.49 μM along with good safety profile of >50-fold in VERO cell line. Thus, this compound could act as a potential lead for further antitubercular studies.