1221156-99-5

Basic information

• Product Name: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene
• Synonyms: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene
• CAS NO: 1221156-99-5
• Molecular Weight: 420.505
• Mol File: 1221156-99-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene(1221156-99-5)
• EPA Substance Registry System: 3'-benzyloxy-4'-ethoxy-3,4,5-trimethoxy stilbene(1221156-99-5)

Safety Data

• Hazardous Substances Data: 1221156-99-5(Hazardous Substances Data)

Upstream product

• 2539-53-9 4-ethoxy-3-hydroxybenzaldehyde 
• 100-44-7 benzyl chloride 
• 74-96-4 ethyl bromide 
• 50773-56-3 3-benzyloxy-4-hydroxybenzaldehyde 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 52987-93-6 2-(4-ethoxy-3-methoxyphenyl)-1,3-dioxolane 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 
• 26691-25-8 3-(benzyloxy)-4-ethoxybenzaldehyde 
• 121-33-5 vanillin 

Downstream Products

• 1221157-00-1 3'-hydroxyl-4'-ethoxy-3,4,5-trimethoxy diphenylethane 
• 1334725-14-2 C₃₃H₃₇O₈P 

Relevant articles and documents

5-FLUOROURACIL DERIVATIVES, PREPARATION METHODS AND USES THEREOF

Disclosed is a 5-fluorouracil derivative having the molecular structure shown in general formula VI, in which Ra and Rb groups are an alkoxy group or a fluorine-substituted alkoxy group having 1, 2, 3, or 4 carbon atoms, and are mono-, bis-, tri-, tetra- or penta-substituted on a phenyl group; a linking group L1 is an alkyl or alkenyl group having 1, 2, 3, or 4 carbon atoms, a linking group L2 is oxygen, or an alkyl or alkoxy group having 1, 2, 3, or 4 carbon atoms, or an amino acid, or an alkyl group having 1, 2, 3, or 4 carbon atoms containing an amino moiety, or a furyl group, and an X group is O or —NH—. Further disclosed is a method for preparing such a derivative and a use of the same in the treatment of cancer, tumor diseases, and diseases caused by abnormal neovascularization in a human or non-human mammal, and a medicament or a composition containing the 5-fluorouracil derivative.

Combretastatin A-4 and Derivatives: Potential Fungicides Targeting Fungal Tubulin

Combretastatin A-4, first isolated from the African willow tree Combretum caffrum, is a tubulin polymerization inhibitor in medicine. It was first postulated as a potential fungicide targeting fungal tubulin for plant disease control in this study. Combretastatin A-4 and its derivatives were synthesized and tested against Rhizoctonia solani and Pyricularia oryzae. Several compounds have EC50 values similar to or better than that of isoprothiolane, which is widely used for rice disease control. Structure-activity relationship study indicated the the cis configuration and hydroxyl group in combretastatin A-4 are crucial to the antifungal effect. Molecular modeling indicated the binding sites of combretastatin A-4 and carbendazim on fungal tubulin are totally different. The bioactivity of combretastatin A-4 and its derivatives against carbendazim-resistant strains was demonstrated in this study. The results provide a new approach for fungicide discovery and fungicide resistance management.