1221252-26-1

Basic information

• Product Name: 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one
• Synonyms: 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one
• CAS NO: 1221252-26-1
• Molecular Weight: 518.615
• Mol File: 1221252-26-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one(1221252-26-1)
• EPA Substance Registry System: 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)-1-methylindolin-2-one(1221252-26-1)

Safety Data

• Hazardous Substances Data: 1221252-26-1(Hazardous Substances Data)

Upstream product

• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 5356-71-8 1,3-diphenyl-1H-pyrazol-5-amine 
• 126-81-8 dimedone 

Relevant articles and documents

Ultrasound-assisted three-component synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en yl)indolin-2-ones in water

Indium(III) chloride was found to be an efficient catalyst for the synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en yl)indolin-2-ones by one-pot, three-component reaction of dimedone, 1H-pyrazol-5-amines and isatins in water under ultrasonic irradiation. The advantages of this method are the use of a readily available catalyst, easy workup, excellent yields, and the use of water as a solvent that is considered to be relatively environmentally benign.