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1221279-04-4

1221279-04-4

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1221279-04-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1221279-04-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,1,2,7 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1221279-04:
(9*1)+(8*2)+(7*2)+(6*1)+(5*2)+(4*7)+(3*9)+(2*0)+(1*4)=114
114 % 10 = 4
So 1221279-04-4 is a valid CAS Registry Number.

1221279-04-4Downstream Products

1221279-04-4Relevant articles and documents

Quinolizidinone carboxylic acids as CNS penetrant, selective M1 allosteric muscarinic receptor modulators

Kuduk, Scott D.,Chang, Ronald K.,Di Marco, Christina N.,Ray, William J.,Ma, Lei,Wittmann, Marion,Seager, Matthew A.,Koeplinger, Kenneth A.,Thompson, Charles D.,Hartman, George D.,Bilodeau, Mark T.

scheme or table, p. 263 - 267 (2010/11/18)

Positive allosteric modulation of the M1 muscarinic receptor represents an approach to treat the cognitive decline in patients with Alzheimer's disease. Replacement of a quinolone ring system in a quinolone carboxylic acid series of M1 modulators with a quinolizidinone bearing a basic amine linkage led to a series of compounds with higher free fraction, enhanced CNS exposure, and improved efficacy in rodent in vivo models of cognition.

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