122129-38-8Relevant articles and documents
Reactions of trifluoromethyl ketones. VIII. Investigation of steric effects of a trifluoromethyl group through ene reaction of trifluoromethyl ketones
Nagai,Nishioka,Koyama,Ando,Miki,Kumadaki
, p. 593 - 598 (2007/10/02)
In the course of our study on the ene reaction of trifluoromethyl ketones, a trifluoromethyl group has been observed to behave as a larger substituent than commonly believed in the biomedicinal field. To estimate the steric eflect of a trifluoromethyl gro