1221398-19-1

Basic information

• Product Name: 5,3'-dihydroxy-8-dimethylamino-3,6,7,4'-tetramethoxyflavone
• CAS NO: 1221398-19-1
• Molecular Weight: 417.416
• Mol File: 1221398-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,3'-dihydroxy-8-dimethylamino-3,6,7,4'-tetramethoxyflavone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,3'-dihydroxy-8-dimethylamino-3,6,7,4'-tetramethoxyflavone(1221398-19-1)
• EPA Substance Registry System: 5,3'-dihydroxy-8-dimethylamino-3,6,7,4'-tetramethoxyflavone(1221398-19-1)

Safety Data

• Hazardous Substances Data: 1221398-19-1(Hazardous Substances Data)

Upstream product

• 1221398-17-9 6,8-dibromo-3,7-O-dimethyltamarixetin 
• 124-41-4 sodium methylate 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin

Semisynthesis of 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (1), a natural flavone that binds with high affinity to tubulin, was performed from hesperidin, the very abundant Citrus flavanone, by a five-step sequence. The last step of the synthesis also gave rise to 5,3'-dihydroxy-3,6,7,4'- tetramethoxyflavone (= casticin or vitexicarpin) (10), 5,3'-dihydroxy-3,7,8,4'- tetramethoxyflavone (= gossypetin 3,7,8,4'-tetramethyl ether) (11), and, unexpectedly, 5,7,3'-trihydroxy-3,6,8,4'-tetramethoxyflavone (12) and 5,3'-dihydroxy-8-dimethylamino-3,6,7,4'-tetramethoxyflavone (= 8-dimethylaminocasticin) (13). Cytotoxicity and antitubulin activity of these five flavones, as well as 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (= ayanin) (14) and intermediate 6,8-dibromo-ayanin (8), were evaluated. Comparison of the responses confirmed and clarified the influence of the A-ring substitution pattern on the biological activity.