1222185-06-9

Basic information

• Product Name: (9H-fluoren-9-yl)methyl 4-aminobenzylcarbamate
• Synonyms: (9H-fluoren-9-yl)methyl 4-aminobenzylcarbamate
• CAS NO: 1222185-06-9
• Molecular Weight: 444.53
• Mol File: 1222185-06-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (9H-fluoren-9-yl)methyl 4-aminobenzylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (9H-fluoren-9-yl)methyl 4-aminobenzylcarbamate(1222185-06-9)
• EPA Substance Registry System: (9H-fluoren-9-yl)methyl 4-aminobenzylcarbamate(1222185-06-9)

Safety Data

• Hazardous Substances Data: 1222185-06-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 159790-81-5 N-(4-aminobenzyl)carbamic acid 9H-fluorenylmethyl ester 

Downstream Products

• 220298-96-4 4‐(tert‐butoxycarbonylamino)benzylamine 

Relevant articles and documents

HISTONE LYSINE DEMETHYLASE INHIBITORS

The invention provides a compound which is an iV-oxalylglycine derivative of formula (I): a hydroxamic acid derivative of formula (II): or a heteroaryl derivative of fomula (III): wherein n; Z1; Z2; Y1; Y2; A; p; X1; X2; m; R4; B; R5; R6; R7; R8; R9; X3; R10; R11 and R12 are as defined herein, or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of the human 2-oxoglutarate-dependant JMJD2 subfamily of histone demethylases, in particular JMJD2E. Such inhibitors are useful in changing the epigenetic state of cells resulting in the inhibition / activation of chromatin remodelling, multiple gene activation / deactivation, and in treating cancer and other conditions characterised by undesirable cellular proliferation, and psychiatric disorders including depression.