1222509-19-4

Basic information

• Product Name: N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2,5-bis-trifluoromethyl-benzamide
• CAS NO: 1222509-19-4
• Molecular Weight: 389.062
• Mol File: 1222509-19-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2,5-bis-trifluoromethyl-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2,5-bis-trifluoromethyl-benzamide(1222509-19-4)
• EPA Substance Registry System: N-(1-hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2,5-bis-trifluoromethyl-benzamide(1222509-19-4)

Safety Data

• Hazardous Substances Data: 1222509-19-4(Hazardous Substances Data)

Upstream product

• 393-82-8 2,5-bis(trifluoromethyl)benzoyl chloride 
• 117098-94-9 (5-amino-2-hydroxymethylphenyl)boronic acid 

Relevant articles and documents

Discovery and structure-activity relationships of 6-(benzoylamino) benzoxaboroles as orally active anti-inflammatory agents

Structure-activity relationships of 6-(benzoylamino)benzoxaborole analogs were investigated for the inhibition of TNF-α, IL-1β, and IL-6 from lipopolysaccharide stimulated peripheral blood mononuclear cells. Compound 1q showed potent activity against all three cytokines with IC50 values between 0.19 and 0.50 μM, inhibited LPS-induced TNF-α and IL-6 elevation in mice and improved collagen-induced arthritis in mice. Compound 1q (AN4161) is considered to be a promising lead for novel anti-inflammatory agent with an excellent pharmacokinetic profile.