1222781-70-5

Basic information

• Product Name: ML 133 Hydrochloride
• Synonyms: ML 133 Hydrochloride;(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;ML133 HCl;1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1);1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride;CID 781301 hydrochloride;N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride;SID 85281105 hydrochloride
• CAS NO: 1222781-70-5
• Molecular Formula: C19H20ClNO
• Molecular Weight: 313.8212
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
• Mol File: 1222781-70-5.mol
• Article Data: 0

Chemical Properties

• Appearance: white to tan/
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: ML 133 Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ML 133 Hydrochloride(1222781-70-5)
• EPA Substance Registry System: ML 133 Hydrochloride(1222781-70-5)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-37/38-41-50/53
• Safety Statements: 26-39-60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1222781-70-5(Hazardous Substances Data)

Usage

Description

ML 133 Hydrochloride is a selective inhibitor of inwardly rectifying Kir2.x potassium channels, which are crucial for maintaining the resting membrane potential in various cell types. It is a hydrochloride salt of ML 133 and exhibits no effect on rKir1.1, making it a specific tool for studying the role of Kir2.x channels in different biological processes.

Uses

Used in Neuroscience Research:
ML 133 Hydrochloride is used as a Kir2.1 blocker for studying the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. This helps researchers understand the role of Kir2 channels in neuronal function and synaptic transmission.
Used in Cortical Neural Activity Studies:
ML 133 Hydrochloride is also used to study the effect of Kir2 on cortical neural activity. By inhibiting Kir2.x channels, researchers can investigate the contribution of these channels to the overall electrical properties of cortical neurons and their involvement in various neurological processes.

Biological Activity

ml133 is a selective potassium channel inhibitor for kir2.1 with ic50 of 1.8 μm (ph 7.4) and 290 nm (ph 8.5), has no effect on kir1.1 and weak activity for kir4.1 and kir7.1.

Biochem/physiol Actions

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.