1222800-79-4

Basic information

• Product Name: ML234
• Synonyms: ML234;ML324;ML243;N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide;NCGC00183808-01
• CAS NO: 1222800-79-4
• Molecular Formula: C21H23N3O2
• Molecular Weight: 349.42622
• Product Categories: Inhibitors
• Mol File: 1222800-79-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 590.1±50.0 °C(Predicted)
• Appearance: white to light brown/
• Density: 1.188±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear
• PKA: 4.71±0.40(Predicted)
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• CAS DataBase Reference: ML234(CAS DataBase Reference)
• NIST Chemistry Reference: ML234(1222800-79-4)
• EPA Substance Registry System: ML234(1222800-79-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1222800-79-4(Hazardous Substances Data)

Usage

Description

ML234, also known as ML-324, is a JMJD2 demethylase inhibitor with the chemical formula (1222800-79-4). It is a compound that inhibits JMJD2 histone demethylases, which play a crucial role in regulating gene expression. ML234 has the ability to repress the expression of viral immediate early genes, specifically for HCMV and HSV-1, with an IC50 of approximately 10 μM. This property allows ML234 to effectively block the initiation of viral lytic infection and prevent HSV-1 reactivation in the sensory ganglia of latently infected mice.

Uses

Used in Antiviral Applications:
ML234 is used as an antiviral agent for its ability to inhibit the reactivation of HSV-1 from the latent state in sensory neurons. This makes it a potential candidate for the development of treatments targeting viral infections, particularly those caused by herpes simplex virus.
Used in Gene Expression Regulation:
ML234 is used as a regulator of gene expression due to its inhibitory effect on JMJD2 histone demethylases. By repressing the expression of viral immediate early genes, ML234 can potentially be employed in the study and manipulation of gene expression pathways, which may have applications in various fields of research and therapeutic development.
Used in Drug Development:
ML234 is used as a starting point for drug development in the pharmaceutical industry. Its unique properties as a JMJD2 demethylase inhibitor and its antiviral capabilities make it a valuable compound for the creation of new drugs targeting viral infections and other related diseases.

References

1) Liang?et al. (2013),?Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency; Sci. Transl. Med.,?5?167ra5