1223405-24-0

Basic information

• Product Name: tert-butyl (4-(3-fluorophenyl)-4-oxobutyl)carbamate
• Synonyms: tert-butyl (4-(3-fluorophenyl)-4-oxobutyl)carbamate
• CAS NO: 1223405-24-0
• Molecular Weight: 281.327
• Mol File: 1223405-24-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (4-(3-fluorophenyl)-4-oxobutyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-(3-fluorophenyl)-4-oxobutyl)carbamate(1223405-24-0)
• EPA Substance Registry System: tert-butyl (4-(3-fluorophenyl)-4-oxobutyl)carbamate(1223405-24-0)

Safety Data

• Hazardous Substances Data: 1223405-24-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1073-06-9 3-fluorobromobenzene 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 

Downstream Products

• 920274-03-9 (R)-2-(3-fluorophenyl)pyrrolidine 
• 920274-04-0 (2S)-2-(3-fluorophenyl)pyrrolidine 
• 1346133-11-6 3-fluoro-4-[4-[[ (2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]methyl]phenoxy]benzamide 

Relevant articles and documents

Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination

Chiral cyclic amines can be prepared via intramolecular reductive amination of N-Boc-protected amino ketones in a one-pot process. With the complex of iridium and f-spiroPhos as the catalyst, a range of N-Boc-protected amino ketones are smoothly transformed into chiral cyclic free amines in high yields and excellent enantioselectivities (up to 97% ee). Moreover, this method can also be successfully applied to the synthesis of a κ-opioid receptor selective antagonist, (S)-1.

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS

Compounds of Formula (I) in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.