122341-38-2 Usage
Description
Temoporfin, also known as Foscan, is a second-generation photosensitizer used in photodynamic therapy (PDT) for the treatment of advanced head and neck cancers. It is a synthetic chlorin that can be synthesized from pyrrole and 3-hydroxybenzaldehyde. Temoporfin has extreme sensitivity to wavelengths of light that penetrate tissues, resulting in lower light/dose and irradiation time. It is well-tolerated and does not preclude surgery or radiotherapy as a later option.
Uses
Used in Oncology:
Temoporfin is used as a photosensitizer for the photodynamic therapy (PDT) of advanced head and neck cancers. It accumulates in tumor cells and, upon light activation (650-652 nm) in the presence of oxygen, generates reactive oxygen species, leading to necrosis and cell death within the tumor.
Used in Palliative Care:
Different approaches to using photodynamic therapy with temoporfin in palliative care are currently of interest. This application aims to provide relief and improve the quality of life for patients with advanced cancer by targeting tumor tissues and reducing tumor burden.
Used in Drug Delivery Systems:
While not explicitly mentioned in the provided materials, temoporfin's use in drug delivery systems could be inferred due to its role as a photosensitizer in PDT. The development of novel drug delivery systems could potentially enhance the delivery, bioavailability, and therapeutic outcomes of temoporfin in cancer treatment.
Originator
Quanta Nova (UK)
Check Digit Verification of cas no
The CAS Registry Mumber 122341-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,3,4 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 122341-38:
(8*1)+(7*2)+(6*2)+(5*3)+(4*4)+(3*1)+(2*3)+(1*8)=82
82 % 10 = 2
So 122341-38-2 is a valid CAS Registry Number.
InChI:InChI=1/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-
122341-38-2Relevant articles and documents
Photobleaching of Compounds of the 5,10,15,20-Tetrakis(m-hydroxyphenyl)-porphyrin Series (m-THPP, m-THPC, and m-THPBC)
Bonnett, Raymond,Martinez, Gabriel
, p. 2013 - 2016 (2002)
(Matrix Presented) 5,10,15,20-Tetrakis(m-hydroxyphenyl)porphyrin (m-THPP) yielded novel quinonoid porphyrins upon irradiation in aqueous methanol. True photobleaching was observed for 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin (m-THPC) and 5,10,15,20-tet
MnO2 instead of quinones as selective oxidant of tetrapyrrolic macrocycles
Nascimento, Bruno F.O.,Rocha Gonsalves, António M.d'A.,Pineiro, Marta
experimental part, p. 395 - 398 (2010/06/12)
Porphyrins and chlorins were generated through dehydrogenation of the corresponding porphyrinogen and bacteriochlorin precursors using activated manganese dioxide and focused microwave irradiation. The application of this inexpensive heterogeneous oxidant under microwave heating conditions, instead of the quinones usually employed in conventional methodologies, allowed short reaction times, simple overall work-ups and good yields.
