1223581-08-5

Basic information

• Product Name: (R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester
• Synonyms: (R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester
• CAS NO: 1223581-08-5
• Molecular Weight: 324.352
• Mol File: 1223581-08-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester(1223581-08-5)
• EPA Substance Registry System: (R)-N-(3-fluoro-4-morpholinylphenyl)oxiranylmethyl carbamic acid ethyl ester(1223581-08-5)

Safety Data

• Hazardous Substances Data: 1223581-08-5(Hazardous Substances Data)

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 565176-83-2 N-ethoxycarbonyl-3-fluoro-4-morpholinyl aniline 

Downstream Products

• 168828-84-0 (R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one 

Relevant articles and documents

A new practical synthesis of linezolid: An antibacterial drug

A novel and practical asymmetric synthesis of (S)-N-[[3-(3-fluoro-4- morpholinyl phenyl)-2-oxo-5-oxazo- lidinyl]methyl]acetamide has been developed by a new approach without recourse to chromatography and it is employed for the synthesis of Linezolid. This involves the reaction of (R)-epichlorohydrin with N-arylcarbamates and subsequent regioselective epoxide ring opening of resulted intermediate by sodium azide.