122395-24-8

Basic information

• Product Name: 4-(4′-chlorophenyl)-2-phenylthiazole
• Synonyms: 4-(4′-chlorophenyl)-2-phenylthiazole
• CAS NO: 122395-24-8
• Molecular Weight: 271.77
• Mol File: 122395-24-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 4-(4′-chlorophenyl)-2-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4′-chlorophenyl)-2-phenylthiazole(122395-24-8)
• EPA Substance Registry System: 4-(4′-chlorophenyl)-2-phenylthiazole(122395-24-8)

Safety Data

• Hazardous Substances Data: 122395-24-8(Hazardous Substances Data)

Upstream product

• 99-91-2 para-chloroacetophenone 
• 100-46-9 benzylamine 
• 873-73-4 4-n-chlorophenylacetylene 
• 2227-79-4 benzenecarbothioamide 
• 2032-36-2 Thiobenzmorpholid 
• 1354970-09-4 1-(1-azido-2-iodoethyl)-4-chlorobenzene 
• 108-90-7 chlorobenzene 
• 937-20-2 p-chlorophenacyl chloride 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 28170-13-0 thiobenzoic acid potassium salt 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 98-80-6 phenylboronic acid 
• 1073-67-2 4-vinylbenzyl chloride 
• 591-50-4 iodobenzene 

Downstream Products

• 18046-21-4 fentiazac 
• 51324-23-3 4,5-di(4-chlorophenyl)-2-phenylthiazole 

Relevant articles and documents

Synthesis of thiazoles and aminothiazoles from β-keto tosylates under supramolecular catalysis in the presence of β-cyclodextrin in water

This is the first report on the supramolecular synthesis of thiazoles/aminothiazoles from β-keto tosylates and thioamide/thiourea in water in the presence of β-cyclodextrin in impressive yields. Formation of inclusion complexes was explained from 1H NMR studies. Copyright Taylor & Francis Group, LLC.

Efficient and expeditious synthesis of di- and trisubstituted thiazoles in PEG under catalyst-free conditions

An efficient and expeditious catalyst-free protocol was developed for the construction of di- and trisubstituted thiazoles from -haloketones and thioureas/thioamides in PEG. The reaction was carried out at ambient temperature, and the products were obtained in excellent isolated yields (91-98%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.

Preparation method of 2, 4-disubstituted thiazole compound

The invention discloses a preparation method of a 2, 4-disubstituted thiazole compound. The method comprises the following steps: carrying out heating reflux reaction on substituted carboxylic acid inthionyl chloride to obtain yellow transparent liquid, and adding dichloromethane to dilute for later use; in an ice bath, slowly dropwise adding the substituted acyl chloride solution into ammonia water while stirring, stirring at room temperature to separate out a white solid, and after the reaction is finished, carrying out suction filtration, washing and drying to obtain substituted amide; carrying out reflux on substituted amide and Lawesson in tetrahydrofuran, carrying out rotary evaporation to remove the solvent after the reaction is finished, and carrying out column purification on thecrude product to obtain substituted sulfamide. The preparation method comprises the following steps: putting substituted sulfamide, ethanol, triethylamine and an alpha-bromocarbonyl compound into a pressure reaction tank, putting the pressure reaction tank into an annular focusing single-mode microwave synthesizer for irradiation, and cooling with compressed air to obtain a target compound. Basedon microwave synthesis, the invention has the advantages of short reaction time, high yield, high heating speed, environment friendliness and the like, and provides a microwave synthesis method of a2, 4-disubstituted thiazole compound.

Visible Light-Induced Difunctionalization of Alkynes: The Synthesis of Thiazoles and 1,1-Dibromo-1-en-3-ynes

A visible light-induced cascade cyclization of thioamides with alkynes was developed to synthesize 1,3-thiozoles. The sulfur radical generated from thioamide via the single-electron transfer (SET) pathway was promoted by photocatalysis as a key intermediate in this reaction. When bromoalkynes were used as the substrate, the self-coupling products 1,1-dibromo-1-en-3-ynes were obtained in moderate yields, and an energy transfer pathway for this transformation promoted by visible-light photocatalysis was proposed.