122411-88-5 Usage
General Description
L-Leucine, N-[[(4-nitrophenyl)methoxy]carbonyl]- is a compound that belongs to the category of amino acid derivatives. It is composed of the amino acid leucine and a nitrophenylmethoxy carbonyl group. This chemical is commonly used in the field of biochemistry and molecular biology as a protective agent for the side-chain amino group of lysine in peptide synthesis. It plays a crucial role in the production of peptides and proteins, and its chemical properties make it useful in the modification and functionalization of biomolecules. Additionally, it has potential applications in the pharmaceutical and biotechnology industries due to its ability to form stable and reversible bonds with other molecules, making it a valuable tool for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 122411-88-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,4,1 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 122411-88:
(8*1)+(7*2)+(6*2)+(5*4)+(4*1)+(3*1)+(2*8)+(1*8)=85
85 % 10 = 5
So 122411-88-5 is a valid CAS Registry Number.
122411-88-5Relevant articles and documents
p-Nitrobenzyloxycarbonyl (pNZ) as a temporary Na-protecting group in orthogonal solid-phase peptide synthesis - Avoiding diketopiperazine and aspartimide formation
Isidro-Llobet, Albert,Guasch-Camell, Judit,Alvarez, Mercedes,Albericio, Fernando
, p. 3031 - 3039 (2007/10/03)
p-Nitrobenzyloxycarbonyl (pNZ) was used as a temporary protecting group for α-amino functionalities in solid-phase peptide synthesis. The corresponding derivatives are readily synthesized solids that perform well on solid phase. The pNZ moiety is orthogonal with the most common protecting groups used in peptide chemistry, and is removed under neutral conditions in the presence of catalytic amounts of acid. The use of pNZ derivatives in conjunction with Fmoc chemistry circumvents typical side reactions associated with the use of piperidine, such as DKP and aspartimide formation. The flexibility of pNZ can be exploited for the preparation of libraries of small organic molecules. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
