122442-01-7

Basic information

• Product Name: (R)-3-PYRROLIDINEACETIC ACID HCL
• Synonyms: (R)-3-PYRROLIDINEACETIC ACID HCL;(S)-3-PYRROLIDINE ACETIC ACID;(R)-3-PYRROLIDINEACETIC ACID;(3R)-Pyrrolidine-3β-acetic acid;[R,(-)]-Homo-β-proline;Pyrrolidine-3β-acetic acid;(R)-3-Pyrrolidineacetic acid hydrochloride;3-Pyrrolidineacetic acid, (3R)-
• CAS NO: 122442-01-7
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 165.62
• Product Categories: pharmacetical
• Mol File: 122442-01-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160-165 °C
• Boiling Point: 303°Cat760mmHg
• Flash Point: 137.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000221mmHg at 25°C
• PKA: 4.43±0.10(Predicted)
• CAS DataBase Reference: (R)-3-PYRROLIDINEACETIC ACID HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-PYRROLIDINEACETIC ACID HCL(122442-01-7)
• EPA Substance Registry System: (R)-3-PYRROLIDINEACETIC ACID HCL(122442-01-7)

Safety Data

• Hazardous Substances Data: 122442-01-7(Hazardous Substances Data)

Usage

General Description

(R)-3-Pyrrolidineacetic acid HCl is a chemical compound that consists of a pyrrolidine ring attached to an acetic acid group, with a hydrochloride salt. (R)-3-PYRROLIDINEACETIC ACID HCL is a chiral molecule, with the (R)-enantiomer being the active form. It is known to have interactions with certain receptor systems in the brain, particularly the GABA and nicotinic acetylcholine receptors, making it of interest in the field of neuropharmacology. Additionally, (R)-3-Pyrrolidineacetic acid HCl has shown potential as a cognition enhancer and has been studied for its potential therapeutic use in treating conditions related to cognitive impairment and memory deficits.

InChI:InChI=1/C6H11NO2.ClH/c8-6(9)3-5-1-2-7-4-5;/h5,7H,1-4H2,(H,8,9);1H/t5-;/m1./s1

Upstream product

• 808157-08-6 ethyl (R)-(+)-2-oxo-1-tert-butoxycarbonyl-4-pyrrolidineacetate 
• 717132-73-5 diethyl 3-(nitromethyl)pentanedioate 
• 216311-66-9 (3R)-2-(1-Benzylpyrrolidin-3-yl)acetic acid 
• 122408-85-9 (3R)-methyl 1-<(R)-1-phenylethyl>pyrrolidine-3-acetate hydrochloride 
• 99735-46-3 methyl (3S)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylate 
• 122408-84-8 (3R)-1-<(R)-1-phenylethyl>-3-(cyanomethyl)pyrrolidine 
• 109960-56-7 (3S)-1-<(R)-1-phenylethyl>-3-(chloromethyl)pyrrolidine 
• 109960-55-6 (3S)-N-<(R)-phenylethyl>-3-(hydroxymethyl)pyrrolidine 
• 915302-94-2 (3RS)-1-<(R)-1-phenylethyl>-5-oxo-3-pyrrolidinecarboxylic acid 
• 97-65-4 2-methylenesuccinic acid 
• 173724-92-0 (3S,4S,1'S)-4-ethenyl-3-methoxycarbonyl-1-(1'-phenylet-1'-yl)pyrrolidin-2-one 
• 174676-77-8 (4S,1'S)-2-<2-oxo-1-(1'-phenyleth-1'-yl)pyrrolidin-4-yl>ethanol 
• 173724-93-1 (4R,1'S)-4-ethenyl-1-(1'-phenyleth-1'-yl)pyrrolidin-2-one 
• 173724-91-9 (S)-N-<2(E)-buten-1-yl>-N-(1-phenyleth-1-yl)methoxycarbonylacetamide 

Downstream Products

• 1334406-71-1 [(R)-1-(6-{tert-butoxycarbonyl-[2-(4-trifluoromethoxyphenyl)ethyl]amino}-2-methoxypyrimidin-4-yl)pyrrolidin-3-yl]acetic acid 

Relevant articles and documents

A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-β- proline

Both enantiomers of the heterocyclic GABA analogue homo-β-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester.

A convenient approach to diastereomerically pure 1,3,4-trisubstituted pyrrolidin-2-ones by intramolecular cyclisation of N-(2-alken-1-yl)amides mediated by Mn(III). An entry to both (R)- and (S)-3-pyrrolidineacetic acid

The oxidative cyclisation of a series of either (S)-N-(2-alken-1-yl)-N-(1-phenyleth-1-yl)-acetoacetamides 5a-d and methoxycarbonylacetamides 6a-b, performed by using Mn(OAc)3 · 2H2O and Cu(OAc)2 · H2O in acetic

GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline

The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABAA receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABAB/s