1224508-38-6

Basic information

• Product Name: 1-(1-cyclohexyl-3-(3-fluorophenyl)prop-2-yn-1-yl)piperidine
• Synonyms: 1-(1-cyclohexyl-3-(3-fluorophenyl)prop-2-yn-1-yl)piperidine
• CAS NO: 1224508-38-6
• Molecular Weight: 299.432
• Mol File: 1224508-38-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1-cyclohexyl-3-(3-fluorophenyl)prop-2-yn-1-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-cyclohexyl-3-(3-fluorophenyl)prop-2-yn-1-yl)piperidine(1224508-38-6)
• EPA Substance Registry System: 1-(1-cyclohexyl-3-(3-fluorophenyl)prop-2-yn-1-yl)piperidine(1224508-38-6)

Safety Data

• Hazardous Substances Data: 1224508-38-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

[Silver(I)(Pyridine-Containing Ligand)] Complexes as unusual catalysts for A3-coupling reactions

Two original macrocyclic silver(I)(pyridine-containing ligand) complexes [Ag(I)(Pc-L)] were synthesized and characterized. Their ability to catalyze the coupling among aldehydes, terminal alkynes and amines (A3-coupling) was demonstrated. The reaction could be performed under conventional as well as dielectric heating. The catalysts were effective in both cases, but dielectric heating allowed a lower catalyst loading and reduced ratio among reaction partners in shorter reaction times. The reaction scope was broad, including aryl/alkyl aldehydes, aryl/alkyl acetylenes and secondary aliphatic amines. Some unprecedented propargylamines have been prepared. The new catalytic system was also tested with more challenging coupling partners such as aniline and ketones.