1224598-18-8

Basic information

• Product Name: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate
• Synonyms: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate
• CAS NO: 1224598-18-8
• Molecular Weight: 537.983
• Mol File: 1224598-18-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate(1224598-18-8)
• EPA Substance Registry System: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate(1224598-18-8)

Safety Data

• Hazardous Substances Data: 1224598-18-8(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 1224598-17-7 ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate 

Relevant articles and documents

Phosphorodiamidate-directed metalation of N -heterocycles using Mg- and Zn-TMP bases

Figure presented The strong directing ability of the N,N,N′,N′- tetramethyldiaminophosphorodiamidate group has been used to achieve selective metalations on various heterocycles such as pyridines, quinolines and quinoxalines with TMP-derived bases like TMPMgCl·LiCl, TMP 2Mg·2LiCl, and TMP2Zn·2MgCl 2·2LiCl. This protocol was applied in the synthesis of etoricoxib, talnetant and a P-selectin inhibitor.