122477-82-1

Basic information

• Product Name: tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate
• Synonyms: tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate
• CAS NO: 122477-82-1
• Molecular Weight: 366.458
• Mol File: 122477-82-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate(122477-82-1)
• EPA Substance Registry System: tert-butyl-N-[(5S)-5-(benzyloxycarbonylamino)-6-hydroxyhexyl]carbamate(122477-82-1)

Safety Data

• Hazardous Substances Data: 122477-82-1(Hazardous Substances Data)

Upstream product

• 53733-99-6 Z-Lys-O-Suc 
• 2389-60-8 Z-Lys(Boc)-OH 
• 2389-49-3 N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-L-lysine methyl ester 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 
• 141925-85-1 ((S)-5-Benzyloxycarbonylamino-6-imidazol-1-yl-6-oxo-hexyl)-carbamic acid tert-butyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1263383-02-3 6-(tert-butoxycarbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl methacrylate 
• 1263383-04-5 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl alcohol 
• 1263383-05-6 6-((2S,4S)-1-(tert-butoxycarbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carbonylamino)-2-(3,4,5-tris(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)benzamido)hexyl methacrylate 
• 1638689-35-6 C₂₂H₃₁N₅O₆ 
• 1622094-01-2 Z-Lys(Boc)ψCH₂I 
• 612547-56-5 (S)-(1-{(S)-5-[(4-cyanobenzenesulfonyl)isobutylamino]-6-hydroxyhexylcarbamoyl}-2,2-diphenylethyl)carbamic acid methyl ester 
• 952574-47-9 (S)-{5-[(4-cyanobenzenesulfonyl)isobutylamino]-6-hydroxyhexyl}carbamic acid tert-butyl ester 
• 612548-30-8 (S)-N-(5-amino-1-hydroxymethylpentyl)-4-cyano-N-isobutyl-benzenesulfonamide 
• 1401318-34-0 C₂₇H₂₉N₅O₃ 
• 1401318-33-9 C₂₆H₂₉N₅O₄S 

Relevant articles and documents

Synthesis of Aminomethylene- gem-bisphosphonates Containing an Aziridine Motif: Studies of the Reaction Scope and Insight into the Mechanism

A broad range of N-carbamoylaziridines were obtained and then treated by the diethyl phosphonate anion to afford α-methylene-gem-bisphosphonate aziridines. Study of the reaction's scope and additional experiments indicates that the transformation proceeds via a new mechanism involving the chelation of lithium ion. This last step is crucial for the reaction to occur and disfavors the aziridine ring-opening. A phosphonate-phosphate rearrangement from a α-hydroxybisphosphonate aziridine intermediate is also proposed for the first time. This reaction provides a simple and convenient method for the synthesis of a highly functionalized phosphonylated aziridine motif.

MACROCYCLIC LIGANDS WITH PENDANT CHELATING MOIETIES AND COMPLEXES THEREOF

The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

INHIBITORS OF LYSINE GINGIPAIN

The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease. In certain embodiments, the invention provides compounds according to Formula I, as described herein, and pharmaceutically acceptable salts thereof.