1224886-30-9Relevant articles and documents
Deoxygenative C2-heteroarylation of quinoline N-oxides: Facile access to α-Triazolylquinolines
Sontakke, Geetanjali S.,Shukla, Rahul K.,Volla, Chandra M. R.
, p. 485 - 493 (2021/03/22)
A metal-and additive-free, highly efficient, step-economical deoxygenative C2-heteroarylation of quinolines and isoquinolines was achieved from readily available N-oxides and N-sulfonyl-1,2,3-Triazoles. A variety of α-Triazolylquinoline derivatives were synthesized with good regioselectivity and in excellent yields under mild reaction conditions. Further, a gram-scale and one-pot synthesis illustrated the efficacy and simplicity of the developed protocol. The current transformation was also found to be compatible for the late-stage modification of natural products.