1224935-95-8Relevant articles and documents
Preparation method of 1-cyclohexylpiperazine
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Paragraph 0025-0027, (2021/04/14)
The invention discloses a preparation method of 1-cyclohexylpiperazine. The method comprises the steps of carrying out reflux reaction on cyclohexyl halide, 1-Boc-piperazine and inorganic base in an organic solvent, filtering after the reaction is finished, and concentrating to obtain an intermediate 1; removing Boc from the intermediate 1 under an acidic condition, drying by distillation after the reaction is finished, pulping with isopropanol, and filtering to obtain solid 1-cyclohexyl piperazine hydrochloride; dissolving with water, adding an inorganic base to adjust the pH value to 12 to 14, extracting with an extraction solvent, drying the solvent by distillation to obtain a crude product of 1-cyclohexylpiperazine, and carrying out reduced pressure distillation on the crude product through an oil pump to obtain a pure product of 1-cyclohexylpiperazine. In the synthesis process of the intermediate 1, use of sodium triacetoxyborohydride and sodium hydroxide is avoided, the production cost is greatly saved, meanwhile, only filtering is needed for aftertreatment, the method is very simple, and time and labor are saved.
ANALGESIC THAT BINDS FILAMIN A
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Page/Page column 84, (2010/05/14)
A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.
