1224946-46-6Relevant articles and documents
Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity
Schuster, Heiko J.,Krewer, Birgit,Von Hof, J. Marian,Schmuck, Kianga,Schuberth, Ingrid,Alves, Frauke,Tietze, Lutz F.
experimental part, p. 1833 - 1842 (2010/08/21)
The synthesis of the first spacer containing, duocarmycin analogue prodrug 11 was realised, its biological properties evaluated and compared to its counterpart prodrug 2 without a spacer unit. The synthesis comprises the manufacture of the new acetylated