122510-78-5

Basic information

• Product Name: 10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one
• Synonyms: 10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one
• CAS NO: 122510-78-5
• Molecular Weight: 304.392
• Mol File: 122510-78-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one(122510-78-5)
• EPA Substance Registry System: 10-benzyl-2-methyl-3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-one(122510-78-5)

Safety Data

• Hazardous Substances Data: 122510-78-5(Hazardous Substances Data)

Upstream product

• 931-20-4 1-methylpiperidin-2-one 
• 5705-15-7 N-benzyl-N-phenylhydrazine hydrochloride 
• 68-12-2 N,N-dimethyl-formamide 
• 72740-33-1 α,α'-hydroxybis(1-methyl-3-methylene-2-piperidone) 
• 89910-21-4 α-hydroxymethylene-N-methyl-δ-valerolactam 

Relevant articles and documents

An improved synthesis of β-carboline and azepino-and azocino[3,4-b]indole derivatives from lactams

The Vilsmeier formylation of butyrolactam, N-methylbutyrolactam, N-methylvalerolactam, and N-methylcaprolactam followed by treatment with aryl hydrazines afforded the 2,3,4,9-tetrahydro-1H-β-carbolin-1-ones, 3,4,5,10-tetrahydroazepino[3,4-b]indol-1(2H)-ones, and 2,3,4,5,6,11-hexahydro- 1H-azocino[3,4-b]indol-1-ones. The synthesis was performed as a one-pot process without isolating the intermediate a-formyl lactams.

REACTIONS OF ARYLHYDRAZINES WITH α-FORMYL DERIVATIVES OF SIX- AND SEVEN-MEMBERED RING LACTAMS

Reactions of α-formyl derivatives of N-methyl-δ-valerolactam and N-methyl-ε-caprolactam with arylhydrazines lead to the formation of 3,4,5,10-tetrahydroazepinoindole-1(2H)-one and 2,3,4,5,6,11-hexahydro-1H-azocinoindol-1-one derivatives.As t