122536-75-8

Basic information

• Product Name: (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE
• Synonyms: 3-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER, (R);(R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE;3-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER;(R)-3-tert-Butoxycarbonylaminopyrrolidine-1-carboxylic acid benzyl ester;(R)-1-Cbz-3-BocaMinopyrrolidin;benzyl (3R)-3-{[(tert-butoxy)carbonyl]aMino}pyrrolidine-1-carboxylate;(R)-benzyl 3-(tert-butoxycarbonyl)pyrrolidine-1-carboxylate
• CAS NO: 122536-75-8
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.38346
• Mol File: 122536-75-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 458.496 °C at 760 mmHg
• Flash Point: 231.091 °C
• Appearance: /
• Density: 1.174 g/cm³
• Vapor Pressure: 1.37E-08mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE(122536-75-8)
• EPA Substance Registry System: (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE(122536-75-8)

Safety Data

• Hazardous Substances Data: 122536-75-8(Hazardous Substances Data)

Usage

General Description

(R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE is a chemical compound with the molecular formula C15H22N2O3. It is a pyrrolidine derivative that contains a BOC-protected amino group and a CBZ-protected carboxylic acid group. (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and bioactive molecules. Its BOC-protected amino group can be selectively deprotected under mild conditions, making it a versatile intermediate in the synthesis of complex organic molecules. Additionally, the CBZ-protected carboxylic acid group can be conveniently activated for subsequent reactions, allowing for efficient and controlled chemical transformations. Overall, (R)-1-CBZ-3-(BOC-AMINO) PYRROLIDINE is a valuable chemical reagent in the production of diverse organic compounds with potential therapeutic applications.

InChI:InChI=1/C17H24N2O4/c1-17(2,3)23-15(20)18-14-9-10-19(11-14)16(21)22-12-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,18,20)/t14-/m1/s1

Upstream product

• 501-53-1 benzyl chloroformate 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 
• 122536-77-0 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine 
• 122536-69-0 (S)-3-<(methylsulfonyl)oxy>-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 122536-71-4 (R)-3-azido-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 100858-32-0 (S)-3-hydroxy-1-pyrrolidinecarboxylic acid phenylmethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122536-73-6 benzyl (R)-3-amino-pyrrolidine-1-carboxylate 

Downstream Products

• 638217-49-9 benzyl (3R)-3-[(tert-butoxycarbonyl)(methyl)amino]pyrrolidine-1-carboxylate 
• 870621-17-3 (R)-Cbz-3-aminopyrrolidine hydrochloride 
• 122536-77-0 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine 

Relevant articles and documents

4, 6-DISUBSTITUTED 2-AMINO-PYRIMIDINES AS HISTAMINE H4 RECEPTOR MODULATORS

The present invention relates to substituted heterocyclic compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides or quaternary ammonium salts thereof wherein constituent members are provided hereinwith, as well as their compositions and methods of use, which are histamine H4 receptor inhibitors/antagonists useful in the treatment of histamine H4 receptor-associated conditions or diseases or disorders including, for example, inflammatory diseases or disorders, pruritus, and pain.

Pyrimidine derivatives

A compound of Formula (I): or a pharmaceutically and/or veterinarily acceptable derivative thereof, wherein R1, R2, R3, R4, R5, and R8 are as defined above.

Quinolone antibacterial agents. Synthesis and structure-activity relationships of a series of amino acid prodrugs of racemic and chiral 7-(3- amino-1-pyrrolidinyl)quinolones. Highly soluble quinolone prodrugs with in vivo pseudomonas activity

A series of amino acid prodrugs of racemic and chiral 7-(3-amino-1- pyrrolidinyl)-6-fluoro-1,8-naphthyridine-3-carboxylic acids, 1-cyclopropyl- 6,8-difluoro-3-quinolinecarboxylic acids, 1-cyclopropyl-6-fluoro-3- quinolinecarboxylic acids, and 5-amino-1-cyclopropyl-6,8-difluoro-3- quinolinecarboxylic acids have been prepared and evaluated for comparative antibacterial activity. Compounds were prepared by acylation of the 3-amino group of the pyrrolidine with common amino acids using standard peptide chemistry. This series has been compared with the parent compounds for antibacterial activity in vitro and in vivo as well as for comparative solubility. The amino acid analogues were less active in vitro, but had equal or increased efficacy in vivo. Indeed, it was proven that these compounds, which were stable to acid and base under the reaction conditions for their preparation, were rapidly cleaved in serum to give the parent quinolones. The amino acid derivatives showed a 3-70 times improved solubility when compared to the parent compounds. The most active compound of the series was [S- (R*,R*)]-7-[3-[(2-amino-1-oxopropyl)-amino]-1-pyrrolidinyl]-1-cyclopropyl- 6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (PD 131112).