122539-65-5Relevant articles and documents
Stereoselective anti-SN2′ Mitsunobu reaction of α-hydroxy-α-alkenylsilanes
Higashino, Masato,Ikeda, Naoko,Shinada, Tetsuro,Sakaguchi, Kazuhiko,Ohfune, Yasufumi
supporting information; experimental part, p. 422 - 425 (2011/03/21)
A novel silyl group-directed anti-SN2′ reaction of allylic alcohols under Mitsunobu reaction conditions is described. The Mitsunobu reaction of α-hydroxy-α-alkenylsilanes with a TBS or TIPS group gave the anti-SN2′ product, in which regio- and stereochemical outcomes of the reaction depended on the steric bulkiness of the silyl group.