122674-99-1

Basic information

• Product Name: (R)-ketoprofen chloroethyl ester
• Synonyms: (R)-ketoprofen chloroethyl ester
• CAS NO: 122674-99-1
• Molecular Weight: 316.784
• Mol File: 122674-99-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-ketoprofen chloroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ketoprofen chloroethyl ester(122674-99-1)
• EPA Substance Registry System: (R)-ketoprofen chloroethyl ester(122674-99-1)

Safety Data

• Hazardous Substances Data: 122674-99-1(Hazardous Substances Data)

Upstream product

• 114315-58-1 2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid 

Relevant articles and documents

Enantioselective inhibition: a strategy for improving the enantioselectivity of biocatalytic systems

Dextromethorphan (DM) and levomethorphan (LM) were found to be effective enantioselective inhibitors of Candida cylindracea lipase-catalyzed hydrolysis of a variety of (±)-arlypropionic and (±)-(arloxy)propionic esters. The enantioselectivity of the biocatalytic resolution of (±)-methyl 2-(2,4-dichlorophenoxy)propionate (DCPP) was enhanced 20-fold in the presence of either DM or LM. A general model for enantioselective inhibition has been developed, and a quantitative expression has been derived to show the underlying parameters that govern enantioselective inhibition. To define the mechanism of action of DM, a series of kinetic inhibition experiments was conducted with enantiomerically pure (R)-(+)-DCPP and (S)-(-)-DCPP. The observed inhibition pattern was that of partial noncompetitive inhibition for (R)-(+)-DCPP and that of pure noncompetitive inhibition for (S)-(-)-DCPP.