1226965-57-6Relevant articles and documents
Method of reducing beta-CF3 substituted alpha,beta-unsaturated ketones
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Paragraph 0025-0059; 0063-0066, (2019/04/17)
The invention relates to a method of reducing beta-CF3 substituted alpha,beta-unsaturated ketones. Benzylamine or substituted benzylamine is in the method for the first time as an intramolecular 1,5-hydrogen transfer agent; under promotion of Lewis acid m
Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization
Guo, Shuo,AbuSalim, Deyaa I.,Cook, Silas P.
supporting information, p. 12378 - 12382 (2018/10/05)
The installation of trifluoromethyl groups has become an essential step across a number of industries such as agrochemicals, drug discovery, and materials. Consequently, the rapid introduction of this critical functional group in a predictable fashion would benefit current practitioners in those fields. This communication describes a mild trifluoromethylation of benzylic C-H bonds with high selectivity for the least hindered hydrogen atom. The reaction provides monotrifluoromethylation and proceeds in an environmentally friendly acetone/water solvent system. The method can be used to install benzylic trifluoromethyl groups on highly functionalized drug molecules.
Iron(II) complexes are suitable catalysts for the isomerization of trifluoromethylated allylic alcohols. Synthesis of trifluoromethylated dihydrochalcones
Cahard, Dominique,Bizet, Vincent,Dai, Xiaoyang,Gaillard, Sylvain,Renaud, Jean-Luc
supporting information, p. 78 - 82 (2013/10/01)
We demonstrated that iron(II) complexes can substitute platinum metals as well as iron(0) carbonyls for the isomerization of γ-trifluoromethylated allylic alcohols into β-trifluoromethylated ketones. In particular, iron(II)-tetra(isonitrile) complexes were employed for the synthesis of a series of trifluoromethylated dihydrochalcones variously decorated on each aromatic ring.