1227174-96-0

Basic information

• Product Name: 1-(4-(2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone
• Synonyms: 1-(4-(2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone
• CAS NO: 1227174-96-0
• Molecular Weight: 440.502
• Mol File: 1227174-96-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-(2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone(1227174-96-0)
• EPA Substance Registry System: 1-(4-(2-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone(1227174-96-0)

Safety Data

• Hazardous Substances Data: 1227174-96-0(Hazardous Substances Data)

Upstream product

• 1227176-36-4 1-(4-(2-(4-((1H-benzo[d]imidazol-2-yl)(hydroxy)methyl)phenoxy)pyridin-3-yl)piperidin-1-yl)ethanone 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 885275-00-3 4-iodo-piperidine-1-carboxylic acid benzyl ester 
• 56441-84-0 ethyl 4-((4-methoxybenzyl)oxy)-benzoate 
• 1227068-38-3 (1H-benzo[d]imidazol-2-yl)(4-((4-methoxybenzyl)oxy)-phenyl)methanone 
• 1227177-84-5 1-(4-(2-fluoropyridin-3-yl)piperidin-1-yl)ethanone 
• 1227060-00-5 (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone 
• 161610-15-7 benzyl 4-(2-fluoropyridin-3-yl)piperidine-1-carboxylate 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Relevant articles and documents

Discovery of clinical candidate 1-(4-(3-(4-(1 H-benzo[ d ]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A)

We report the identification of a PDE10A clinical candidate by optimizing potency and in vivo efficacy of promising keto-benzimidazole leads 1 and 2. Significant increase in biochemical potency was observed when the saturated rings on morpholine 1 and N-a