1227199-81-6

Basic information

• Product Name: 5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole
• Synonyms: 5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole
• CAS NO: 1227199-81-6
• Molecular Weight: 311.181
• Mol File: 1227199-81-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole(1227199-81-6)
• EPA Substance Registry System: 5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole(1227199-81-6)

Safety Data

• Hazardous Substances Data: 1227199-81-6(Hazardous Substances Data)

Upstream product

• 50800-56-1 5-(4-bromophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo<2,1-a>isoindole 

Downstream Products

• 1227196-49-7 5-benzyl-5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindole 
• 1227199-94-1 tert-butyl [5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-5-yl]acetate 
• 1242246-94-1 C₁₈H₁₃BrN₂O₂ 
• 1242246-95-2 C₂₃H₂₃BrN₂O₂ 

Relevant articles and documents

Tricyclic imidazole antagonists of the Neuropeptide S Receptor

A new structural class of potent antagonists of the Neuropeptide S Receptor (NPSR) is reported. High-throughput screening identified a tricyclic imidazole antagonist of NPSR, and medicinal chemistry optimization of this structure was undertaken to improve potency against the receptor as well as CNS penetration. Detailed herein are synthetic and medicinal chemistry studies that led to the identification of antagonists 15 and NPSR-PI1, which demonstrate potent in vitro NPSR antagonism and central exposure in vivo.