1227465-31-7

Basic information

• Product Name: 2-(3,4-dihydroxyphenyl)ethyl 3,4-dihydroxybenzoate
• Synonyms: 2-(3,4-dihydroxyphenyl)ethyl 3,4-dihydroxybenzoate
• CAS NO: 1227465-31-7
• Molecular Weight: 290.273
• Mol File: 1227465-31-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dihydroxyphenyl)ethyl 3,4-dihydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dihydroxyphenyl)ethyl 3,4-dihydroxybenzoate(1227465-31-7)
• EPA Substance Registry System: 2-(3,4-dihydroxyphenyl)ethyl 3,4-dihydroxybenzoate(1227465-31-7)

Safety Data

• Hazardous Substances Data: 1227465-31-7(Hazardous Substances Data)

Upstream product

• 99-50-3 3,4-Dihydroxybenzoic acid 
• 10597-60-1 hydroxytyrosol 

Relevant articles and documents

Synthesis and evaluation of the platelet antiaggregant properties of phenolic antioxidants structurally related to rosmarinic acid

Polyphenols, such as rosmarinic acid, are widely distributed natural products with relevant antioxidant activity. Oxidative stress plays an important role in the pathogenesis of a number of disorders. Here, we report on the synthesis and biological effects of the polyphenolic esters hydroxytyrosyl gallate (1), hydroxytyrosyl protocatechuate (2) and hydroxytyrosyl caffeate (3), structurally related to rosmarinic acid. The three compounds showed a greater free radical scavenging activity than their precursors and also than rosmarinic acid. Esters 1 and 3 significantly reduced thrombin-evoked platelet aggregation, which is likely mediated to the attenuation of thrombin-stimulated Ca2+ release and entry. The three compounds reduced the ability of platelets to accumulate Ca2+ in the intracellular stores, probably by enhancing the Ca2+ leakage rate and reduced store-operated Ca2+ entry in these cells. These observations suggest that the structurally-simplified analogs to rosmarinic acid, compounds 1 and 3, might be the base of therapeutic strategies to prevent thrombotic complications associated to platelet hyperaggregability due to oxidative stress.