1227472-26-5

Basic information

• Product Name: tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• Synonyms: tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS NO: 1227472-26-5
• Molecular Weight: 401.426
• Mol File: 1227472-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(1227472-26-5)
• EPA Substance Registry System: tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate(1227472-26-5)

Safety Data

• Hazardous Substances Data: 1227472-26-5(Hazardous Substances Data)

Upstream product

• 2252-44-0 1-bromo-3-(trifluoromethoxy)benzene 
• 898157-46-5 tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 203662-51-5 1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine 
• 240401-09-6 tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate 
• 954236-44-3 tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1227472-25-4 (3RS)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane hydrochloride 
• 179113-90-7 (3-(trifluoromethoxy)phenyl)boronic acid 

Downstream Products

• 1227472-02-7 (3RS)-N-(3,4-dimethylisoxazol-5-yl)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxamide 
• 1227566-37-1 C₁₅H₁₈F₃NO₂ 
• 1227472-28-7 tert-butyl (3R)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 1227472-31-2 tert-butyl (3S)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate 
• 1227472-25-4 (3RS)-3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane hydrochloride 

Relevant articles and documents

HETEROCYCLIC SPIRO COMPOUNDS AS MAGL INHIBITORS

The present invention provides, in part, heterocyclic spiro compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or sa

1-OXA-8-AZASPIRO [4, 5 ] DECANE- 8 -CARBOXAMIDE COMPOUNDS AS FAAH INHIBITORS

Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I wherein Ar1, Ar2, R1, R2, R3 and R4 are as defined herein and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.