122752-21-0 Usage
Description
Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3
References
1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710
2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614
3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151
Check Digit Verification of cas no
The CAS Registry Mumber 122752-21-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,7,5 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122752-21:
(8*1)+(7*2)+(6*2)+(5*7)+(4*5)+(3*2)+(2*2)+(1*1)=100
100 % 10 = 0
So 122752-21-0 is a valid CAS Registry Number.
InChI:InChI=1/C52H74N4O17/c1-30(19-20-42(73-52(62)45(66-11)28-63-8)34(5)48(71-35(6)58)31(2)21-22-56(7)29-57)43(65-10)24-44-33(4)41(64-9)17-14-18-46-53-38(26-68-46)50-55-39(27-70-50)51-54-37(25-69-51)49(67-12)32(3)40(60)16-13-15-36(59)23-47(61)72-44/h13-14,16,18,21-22,25-27,29-34,36,41-45,48-49,59H,15,17,19-20,23-24,28H2,1-12H3/b16-13+,18-14-,22-21+/t30-,31+,32-,33+,34-,36-,41-,42+,43-,44+,45+,48+,49-/m0/s1