122757-53-3

Basic information

• Product Name: 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine
• Synonyms: 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine;1-(2,3-Dideoxy-2-fluoro-β-D-glycero-penta-2-enofuranosyl)cytosine;1-[3-Fluoro-5β-(hydroxymethyl)-2,5-dihydrofuran-2β-yl]cytosine;2'-Fluoro-2',3'-didehydro-2',3'-dideoxycytidine
• CAS NO: 122757-53-3
• Molecular Formula: C9H10FN3O3
• Molecular Weight: 227.1924032
• Mol File: 122757-53-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434.4°Cat760mmHg
• Flash Point: 216.5°C
• Appearance: /
• Density: 1.66g/cm³
• CAS DataBase Reference: 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine(122757-53-3)
• EPA Substance Registry System: 2',3'-dideoxy-2',3'-didehydro-2'-fluorocytidine(122757-53-3)

Safety Data

• Hazardous Substances Data: 122757-53-3(Hazardous Substances Data)

Upstream product

• 69123-98-4 fialuridine 
• 69123-94-0 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil 
• 124424-33-5 1-<3-O-(methylsulfonyl)-5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl)uracil 
• 128496-11-7 1-<2-deoxy-2-fluor-3-O-(methylsulfonyl)-5-O-trityl-β-D-arabinofuranosyl>)uracil 
• 124424-35-7 1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil 
• 124424-27-7 1-<5-O-(momomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>uracil 
• 124424-34-6 O-2,3'-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>uracil 
• 128496-13-9 2',3'-dideoxy-2',3'-didehydro-3'-fluoro-5'-O-trityluridine 
• 128496-12-8 (1R,9S,10R,12S)-12-Fluoro-10-trityloxymethyl-8,11-dioxa-2,6-diaza-tricyclo[7.2.1.0^2,7]dodeca-3,6-dien-5-one 
• 128496-10-6 1-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)uracil 
• 128496-14-0 5'-O-acetyl-2',3'-dideoxy-2',3'-didehydro-3'-fluorouridine 
• 122757-52-2 2',3'-dideoxy-2',3'-didehydro-3'-fluorouridine 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 405238-85-9 1-[5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-2-fluoro-β-D-glycero-pent-2-enofuranosyl]-N⁴-benzoylcytosine 

Relevant articles and documents

Structure-activity relationships of 2′-fluoro-2′,3′-unsaturated d-nucleosides as anti-hiv-1 agents

We studied the structure-activity relationships of a series of 2′-fluoro-2′,3′-unsaturated D-nucleosides against HIV-1 in human peripheral blood mononuclear (PBM) cells. The target compounds 10-21 and 28-33 were prepared by N-glycosylation of the acetate

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)

A range of 2'-fluoro and 2',3'-difluoro analogues of pyrimidine deoxyribonucleosides have been synthesized and evaluaed against human immunodeficiency virus (HIV-1) in a human lymphoblastoid cell line. Among these compounds, 1-(2,3-dideoxy-2-fluoro-β-D-threopentofuranosyl)cytosine (12), 2',3'-didehydro-2',3'-dideoxy-2'-fluorocytidine (35), 1-(2,3-dideoxy-2,3-difluoro-β-D-arabinofuranosyl)cytosine (41), and 3'-deoxy-2',3'-didehydro-2'-fluorothymidine (45) were found to have significant antiviral activity, with IC50 values of 0.65, 10, 10, and 100 μM, respectively. The structure-activity relationships are discussed.