1227618-09-8Relevant articles and documents
A highly effective one-pot synthesis of quinolines from 2-alkynylnitrobenzenes
Okuma, Kentaro,Ozaki, Saori,Seto, Jun-Ichi,Nagahora, Noriyoshi,Shioji, Kosei
, p. 935 - 942 (2010)
A highly effective one-pot synthesis of poly-substituted quinolines from 2-alkynylnitrobenzenes using inexpensive reagents has been developed. Reaction of 2-alkynylnitrobenzenes with Sn/HCl in EtOH resulted in the formation of 2-aminophenyl ketones and subsequently condensed in situ with ketones to form tri-substituted quinolines in 80-97% yields.